Macrodosing is a twice weekly macrodose of knowledge on topics ranging anywhere from your favorite conspiracy theory to deep dives on historical events. With PFT Commenter and Arian Foster at the helm of their cast of characters, the only criteria for this podcast is that we tickle your brain. You can find every episode of this show on Apple Podcasts, Spotify or YouTube. Prime Members can listen ad-free on Amazon Music. For more, visit barstool.link/macrodosing
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Is it possible to feel safe at work? Neurobiology expert Rajkumari Neogy absolutely thinks so. Join us for conversations that will blow your mind as we explore what it takes to foster inclusive leadership and cultivate resonant cultures in the workplace.
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With the convergence of data, computing power, and new methods, computational biology is at its most exciting moment. At PSI, we're asking the leading researchers in the field to discover where we're headed for, and which exciting pathways will take us there. Whether you're just thinking of starting your research career or have been computing stuff for decades, come and join the conversation!
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The Karen Read Case (ft. Chief) | Aug 1, 2024
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On today’s episode, Chief joins Big T and Arian to discuss the Karen Read Trial. They’ll get into the details surrounding her life, the allegations against her, and the impact of her story on the public. Plus, we look at some current events including Kamala’s most recent campaign, former Alabama football player with 40 pounds of weed, Joe Milton’s …
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Breaking Down the Controversial Opening Ceremony | Jul 30, 2024
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On today’s episode chaps joins Big T and Arian to discuss the Olympic opening ceremony, the presidential election, Big T’s latest Teed off and much more. Enjoy! (00:08:03) Olympic Opening Ceremony (00:36:42) Presidential Election (01:11:07) Teed Off(01:25:03) Voicemails You can find every episode of this show on Apple Podcasts, Spotify or YouTube. …
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Let Go of Having All the Answers w/ Jon Low
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As a leader, it’s tempting to feel like you need to have all the answers. Being a great problem solver helped you get to where you are, but once you start leading a team, you need to evolve into someone who enables problem-solving. “Performance is a team sport, not a solo act,” says Jon Low, a performance coach and tactical advisor to early-stage f…
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Caffeine's Role in Shaping Civilization | Jul 25, 2024
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In this episode, we dive into the history and impact of caffeine and coffee on civilization. Plus, Jerry joins the crew and the guys discuss NFL training camp, Donald Trump vs. Bryson Dechambeau golf match and much more.(00:12:45) Rumor of Top Gun 3 (00:19:33) NFL Training Camp(01:01:16) Donald Trump vs. Bryson Dechambeau (01:19:03) History of Coff…
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Joe Biden Drops Out of the 2024 Presidential Race | Jul 23, 2024
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On today’s episode the crew is back to discuss Biden’s withdrawal from the presidential election, Arian’s first coffee experience, the Microsoft tech outage, answer some voicemails and much more. Plus, we have an interview with Television film director/writer, Robert Kiviat, to discuss his new documentary "The Mandela Effect Phenomenon". Enjoy!(00:…
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Unusual Scriptures from the Bible (ft. Dan McClellan) | July 18, 2024
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In today’s episode, we dive into the Bible's most unusual and intriguing stories with Uncle chaps and special guest Dan McClellan, a PhD in Theology & Religion. We discuss lesser-known narratives and characters from the Bible and get Dan’s take on religion. Plus, we get into Donald Trump’s and his political campaign, Arian’s Disney vacation, a woma…
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Episode 16½ - End-of-season 2 commentary
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Send us a Text Message.Von Miłosz Wieczór
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The Attempted Assassination of Donald Trump | July 16, 2024
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On today’s episode, Chaps joins to discuss the attempted assassination on former President Donald Trump. We break down the details of the plot, the security measures in place, and the implications for his political future. Plus, we get into the Copa America finals, the firing of USMNT coach Greg Berhalter, the release of College Football 25 and muc…
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How to Have Antiracist Conversations w/ Dr. Roxy Manning
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Can we really challenge racism with both fierceness and compassion? Can we confront discriminatory actions head-on without shaming others, and interrupt hate in ways that foster genuine change? Using Dr. Martin Luther King Jr.'s Beloved Community framework, activists are finding new ways to create equity through bold yet empathetic dialogue against…
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Getting Ready For The Paris Olympics (ft. Jeff D. Lowe and Chaps) | Jul 11, 2024
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On today’s episode we’re joined by Jeff D. Lowe and Chaps to explore the history of the Olympics. From their ancient origins in Olympia, Greece, to the global phenomenon they are today, we'll uncover the evolution, key moments, and the spirit that drives the Olympics. Plus, we get into Trump challenging Biden to a golf match, the men’s olympic bask…
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Episode 16 - Janusz Bujnicki: Structural modeling, RNA modifications, and advising policy-makers on science
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Send us a Text Message. In the sixteenth episode, Janusz Bujnicki tells me about his early switch to bioinformatics, a stroke of serendipity that defined his future career, and how he later managed to reincorporate both biophysics and experimental biology into his research agenda. We talk about the current state of the field of RNA structural predi…
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Big T Almost Lost His Arm Over Break | Jul 9, 2024
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On today’s episode the guys recap their 4th of July break, rank the top 10 best midwest cities, discuss the presidential debate and much more. Enjoy!(00:01:39) 4th of July break recap (00:22:20) Midwest cities(00:35:18) Presidential debate(00:53:57) PFT’s el camino + Greece trip(01:05:24) Boeing is pleading guilty You can find every episode of this…
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Episode 15 - Paulo CT Souza: Developing a universal coarse-grained force field, and approaching the science of molecular complexity
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Send us a Text Message. In the fifteenth episode, Paulo Souza and I discuss the challenges inherent in managing a project of such a scope, and the philosophy behind the systematic way in which Martini is continuously improved and reparameterized. Paulo describes how a user-centric approach helps refine and troubleshoot the model through its widesca…
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Answering Voicemails & Giving Relationship Advice - Macrodosing | July 2, 2024
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On today's episode we answer listen voicemails and tackle relationships, riddles, life advice and much more. (Plus, Arian learns what a cat cafe is). Enjoy! You can find every episode of this show on Apple Podcasts, Spotify or YouTube. Prime Members can listen ad-free on Amazon Music. For more, visit barstool.link/macrodosing…
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To Stop Trauma, Learn from Children w/ Rainbow Markell
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“Even a momentary lack of love and safety as children can follow us for the rest of our lives,” says Rainbow Markell, an early childhood education expert. Since her start in the field in the 1970s, she has been part of some of the most forward-thinking programs that put the idea of “trauma-informed care” on the map. How do you help children identif…
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Tales of the Greek Gods - Jun 27, 2024
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In today’s episode we’re joined by Nick and Wonton Don to discuss the pantheon of Greek gods. Join us as we explore the origins, powers, and personalities of the Olympian deities who ruled the ancient world from their celestial abode on Mount Olympus.We'll delve into the mighty Zeus, the king of the gods, and his complex relationships with his divi…
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Could Arian Compete In The Olympics? | Jun 25, 2024
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On today’s episode we check in on Big T live from Omaha, plus, the guys get into Kendrick Lamar, the Trump vs. Biden debate coming up this week, the Paris Olympics, Boeing executives and much more. Enjoy! You can find every episode of this show on Apple Podcasts, Spotify or YouTube. Prime Members can listen ad-free on Amazon Music. For more, visit …
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Episode 14 - Syma Khalid: New ways to fight bacteria, the bacterial envelope, and kindness & openness in academia
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Send us a Text Message. In the fourteenth episode, Syma Khalid and I talk about the challenges we're faced with when trying to understand the environment of the bacterial cell envelope, and the outer membrane in particular. We discuss how the lessons taken from the computational study of these structures can inform the design of future antibacteria…
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Are Reptilians Living Among Us? | Jun 20, 2024
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On today’s episode we dive deep into the enigmatic world of Reptilian conspiracies. From the origins of the theory to the key figures who propagate it, we unravel the layers of this fascinating and controversial belief. Join us as we explore the claims that a hidden reptilian elite controls the world, examine the evidence presented by conspiracy th…
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PFT Got Robbed and Didn’t Even Know It | Jun 18, 2024
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On today's episode we get into PFT and Big T's teed off. Plus, Jersey Jerry joins us to answer your voicemails. Enjoy!(00:05:38) PFTeed off (Gym membership) (00:19:56) Chuck Schumer’s meat (00:28:32) Jerry joins (00:43:32) Teed off (Concerts) (01:06:10) Voicemails You can find every episode of this show on Apple Podcasts, Spotify or YouTube. Prime …
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Episode 13 - Daniel Zuckerman: Trajectory ensembles, writing books, and learning biology through physics
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Send us a Text Message. In the thirteenth episode, Daniel Zuckerman and I talk about textbooks on statistical biophysics and a physics-based vision of biology, a few of which he himself authored. Daniel reveals that his passion for clarity in writing comes from his early humanities background, and makes a case for how well-thought and physically mo…
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How Can Leaders Think Creatively? w/ Culturati CEO Eugene Sepulveda
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By championing creative thinking, leaders cultivate a space where ideas flourish, collaboration thrives, and the extraordinary becomes possible, paving the way for sustainable success and growth. "Yet we don't program time for leaders to be creative," says Eugene Sepulveda. "When can they let their mind relax and daydream? The best organizations cr…
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Exploring the Life and Legacy of Sigmund Freud | Jun 13, 2024
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In this episode, we delve into the fascinating life and enduring legacy of Sigmund Freud, the father of psychoanalysis. Join us as we explore Freud's early years and academic journey, uncovering the experiences and influences that shaped his groundbreaking work. We'll discuss his most influential theories, including the concepts of the unconscious …
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Episode 12 - Vlad Cojocaru: Simulating transcriptional regulation, returning to our home countries, and the scales of the genome
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Send us a Text Message. In the twelfth episode, Vlad Cojocaru and I discuss how the simulation field can integrate further layers of complexity in modeling transcription control and genome organization in humans. Vlad shares his insights on the computational biology of transcription factors, including DNA-mediated allostery and pioneer transcriptio…
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San Diego Recap + The Worst Day of Big T’s Life | June 10, 2024
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On today’s episode we recap our trip to San Diego including Arian’s first pitch, Big T getting drunk and much more. Plus, we discuss Dan Hurley and The Lakers, Gregg Berhalter & USA Soccer and answer your voicemails.(00:01:55) San Diego Recap(00:25:49) Dan Hurley + The Lakers(00:31:00) Gregg Berhalter & USA Soccer (00:45:23) Voicemails You can find…
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Exploring The Conspiracy Behind The Lincoln Assassination | Jun 6, 2024
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In this episode, we delve into the intricate web of conspiracy theories surrounding the assassination of President Abraham Lincoln. Join us as we explore the events leading up to that fateful night at Ford's Theatre, the key figures involved, and the numerous theories that suggest a broader plot beyond John Wilkes Booth's infamous act. Was it merel…
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Trump's Legal Battles: Discussing the Convictions | Jun 4, 2024
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In this jam-packed episode, we dive into some of the most talked-about news stories making headlines. First, we provide an update on the man caught driving with a suspended license while attending his Zoom court hearing. Next, we explore the bizarre and escalating incidents of orcas attacking boats, examining the possible reasons behind this unusua…
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Viewing Homelessness Through a Human Lens w/ Social Worker Ariane Porras
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The homelessness crisis in the United States is at an all-time high, with 653,000 people experiencing homelessness on any given night, the highest number since 2007. Homelessness involves complex factors such as mental health, economic instability, and inadequate social support. Yet recently, a Supreme Court case debated whether sleeping on the str…
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Inside the World of Political Coups | May 30, 2024
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In this episode, we delve into the tumultuous world of political coups, exploring their causes, mechanics, and impacts on modern history. From the dramatic overthrows of governments to the intricate power plays behind the scenes, we examine how coups have shaped nations and altered the course of political landscapes. Join us as we unpack notable co…
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Episode 11 - Justin Lemkul: Providing technical help online, sharing expertise, and polarization in nucleic acids
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Send us a Text Message. In the eleventh episode, Justin Lemkul and I talk about the motivations and challenges behind providing technical help on online forums and mailing lists. Justin shares his story of becoming a prolific technical advisor for the Gromacs community, which evolves into a discussion about automatability, the role of expertise in …
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Solving Riddles With Jersey Jerry | May 28th, 2024
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Answering your voicemails(00:04:02) Apple Music top albums (00:13:35) Riddles(00:23:48) Harrison Butker(00:30:14) P. Diddy(00:32:48) Favorite song ever written (00:48:11) What would you name a horse(00:51:48) Picking up girls at the gym (01:08:13) Hitting on girls at the gym(01:10:54) Riddles You can find every episode of this show on Apple Podcast…
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Inside Private Equity: Power, Controversy, and Sports | May 23, 2024
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In this episode, we dive deep into the world of private equity, unraveling what it is and how it operates. We'll explore the controversies and criticisms surrounding this often-misunderstood sector, from its impact on companies to the broader economic implications. Additionally, we'll examine private equity's growing influence in professional sport…
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Episode 10 - Ariane Nunes-Alves: Kinetics in drug design, molecular crowding, and the social life of a PI
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Send us a Text Message. In the tenth episode, Ariane Nunes-Alves and I talk about a kinetics-centric view of drug design, making the case that modeling kinetics in atomistic simulation is an important frontier that, despite clear biomedical relevance, is rarely explicitly addressed either in model parameterization or with the latest AI methods. We …
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Our Reaction to the Scottie Scheffler Arrest | May 21, 2024
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On today's Nanodose, the guys dive into the unexpected story of Scottie Scheffler's arrest, examine the latest news on Iran’s president, debate the merits of tennis versus pickleball, and share their thoughts on some notorious bad preachers. Plus, there's a lot more in store, so tune in for an episode packed with lively discussions and unexpected t…
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Is DEI Headed for Extinction? w/ Cindy Owyoung
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In the past few years, DEI efforts in the U.S. have hit some setbacks. Political divides have deepened, with some states passing laws that limit conversations about race and gender, and the Supreme Court ruling against affirmative action in the workplace. "I've been here before," says Cindy Owyoung, who has been at the forefront of DEI for over 20 …
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Mermaids and Psychedelics: Diving into Myth and Mind (ft. Jake Plummer) | May 16, 2024
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Dive into the mystical and mind-bending world of mermaids and psychedelics in today’s episode with our special guest, former NFL quarterback Jake Plummer. We explore ancient myths and modern tales of these enchanting sea beings, delving into their symbolic connections to our subconscious minds. Join us as we discuss the intriguing intersections of …
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Episode 9 - Michele Vendruscolo: Preventing protein misfolding, fostering public engagement of scientists, and AI tools in drug design
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Send us a Text Message. In the ninth episode, Michele Vendruscolo and I discuss the current state of research on misfolding diseases, typically associated with excessive protein aggregation and formation of insoluble amyloids. Michele presents an optimistic perspective in which the convergence of recent clinical and software developments opens up n…
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Large Explains Roaring Kitty’s Meme Stocks | May 14, 2024
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In today’s episode we get into the world of meme stocks and the internet phenomenon that turned Wall Street on its head. Large joins us to unravel the incredible story of Roaring Kitty, the YouTube and Reddit persona who became a key figure in the GameStop stock saga. Plus, we get into the Miss USA controversy, Ashley Biden’s diary, and voicemails.…
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Diving into DARPA | May 9, 2024
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Join us as we delve deep into the secretive world of DARPA, the Defense Advanced Research Projects Agency. Uncover the fascinating history of this enigmatic organization, from its inception in response to the Soviet Union's launch of Sputnik to its groundbreaking innovations that have shaped the modern world.Explore DARPA's most noteworthy inventio…
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Joe Biden Has 24 Hours To Respond | May 7, 2024
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On today’s dynamic episode, we dive deep into the latest developments in the rap world, starting with the ongoing saga between Drake and Kendrick Lamar. Get the latest updates on their lyrical feud and how it's shaping the landscape of modern hip-hop. Plus, Big T hops in on the rap beef and gives us a diss track aimed at none other than Joe Biden.S…
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Unraveling the OJ Simpson Trial + A Send Off To Billy Football | Thu May 2, 2024
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In today’s episode, we get into the infamous OJ Simpson Trial, exploring its intricate details, shocking twists, and enduring cultural impact. Join us as we unravel the complexities of the case, from the murder of Nicole Brown Simpson and Ron Goldman to the dramatic courtroom proceedings that captivated the nation. We examine the evidence, the lega…
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Big T Goes Off About The Falcons Draft Pick | Macrodosing - April 30, 2024
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In this week's episode, we dive into all things happening in the news. First up, we dissect the shocking controversy surrounding South Dakota Governor Kristi Noem's defense of her controversial act. Then, join us as we explore the saga of Arian's attempt to cancel his LA Fitness membership—spoiler alert: he is NOT happy with them. Plus, Big T break…
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A Journey Through the History of Sports Drafts | Macrodosing - Apr 25, 2024
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On today’s episode we dive into the captivating history of sports drafts. From humble beginnings to multi-billion dollar industries, we explore how drafts have evolved across various sports, shaping the landscape of competition and player recruitment. Discover the stories behind iconic draft moments, the strategies employed by teams and leagues, an…
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Arian Is Back in Chicago! | Nanodosing - Apr 23, 2024
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On today’s episode everyone is back and Arian is IN STUDIO in Chicago!! We get into Taylor Swift’s new album, Arian’s problem with people traveling first class, NBA contracts and how the game has changed over the years, Zach Wilson to the Broncos and the new NFL uniforms. Plus, Hank joins the show to chat with Arian about our continued conversation…
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A Hard Look at White Supremacy w/ Jill Nagle
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White supremacy isn’t just in the history books; it’s baked into our daily lives, from the shows we watch to the ways we work, often without us even noticing. "It's the water that we swim in. And we don't know because we're the fish," says Jill Nagle. Jill has written multiple books, created a somatic counseling approach called Wisdom of the Body, …
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The Rise of Cyber Warfare (ft. Jersey Jerry)
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In today's episode, we’re joined by Jersey Jerry to discuss the intricate world of cyber security and cyber warfare. Join us as we explore the evolving landscape of digital threats, from ransomware attacks to state-sponsored cyber espionage. Learn how governments, businesses, and individuals can protect their digital assets and stay ahead in the on…
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Episode 8½ - My commentary: Wrapping up the first season
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Send us a Text Message. In this episode, I'm attempting to string together the most common threads brought up by my guests in the first eight interviews on the podcast. Reflecting on these conversations, I'm suggesting some grand challenges for the field in the years to come.Von Miłosz Wieczór
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Secret Food Formulas (Part 2) | Nanodosing - April 16, 2024
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On today’s episode we continue the conversation on secret food formulas. We get into the secretive realms of renowned brands like Krispy Kreme, Dr. Pepper, Hershey's Chocolate, Heinz Ketchup, and more.From the irresistible melt-in-your-mouth sweetness of Krispy Kreme's original glazed donuts to the unique blend of 23 flavors in Dr. Pepper, discover…
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Inside the World of Secret Food Formulas | Apr 11, 2024
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Step into the world of culinary alchemy as we explore the fascinating realm of secret food formulas. In this episode, we talk about some of the most iconic and closely guarded recipes in the food industry, including the formula behind Coca-Cola's signature taste and the legendary blend of herbs and spices that defines KFC's finger-licking good chic…
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Episode 8 - Rossen Apostolov: Managing scientific collaboration, the biggest project of European biophysics, and seeding schools of thought
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Send us a Text Message. In the eight episode, Rossen Apostolov and I depart from the standard format to talk about the core concepts behind BioExcel, the European Center of Excellence for computational biology. We discuss their main objectives and challenges, from working with code to organizing schools and webinars, talk about the challenges of su…
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