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XPC #11: Fei Chen - Expansion Microscopy, Spatial Transcriptomics, Spatial Genomics
Manage episode 323761819 series 3002157
Inhalt bereitgestellt von Loyd Waites and Bobby Johnston, Loyd Waites, and Bobby Johnston. Alle Podcast-Inhalte, einschließlich Episoden, Grafiken und Podcast-Beschreibungen, werden direkt von Loyd Waites and Bobby Johnston, Loyd Waites, and Bobby Johnston oder seinem Podcast-Plattformpartner hochgeladen und bereitgestellt. Wenn Sie glauben, dass jemand Ihr urheberrechtlich geschütztes Werk ohne Ihre Erlaubnis nutzt, können Sie dem hier beschriebenen Verfahren folgen https://de.player.fm/legal.
The Xapiens Podcast (XPC) Episode 11:
Join Xapiens Co-Director Bobby Johnston in a discussion with Fei Chen. Fei is a core institute member at the Broad Institute of MIT and Harvard and an assistant professor in the Department of Stem Cell and Regenerative Biology at Harvard University. During the course of his doctoral research, Chen co-invented Expansion Microscopy. He completed his undergraduate degree at CalTech in EE before coming to MIT for his Ph.D. in biological engineering. Fei can sometimes be found playing basketball around MIT, which is how Bobby first met him, and eventually convinced him to talk on the podcast.
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Other Xapiens Info:
XPC Channel: https://www.youtube.com/channel/UCKCp2QLDdzA3nuhdkRkJwXQ
Xapiens Home: https://xapiens.mit.edu/
RELEVANT LINKS:
Fei Chen Lab: https://www.broadinstitute.org/bios/fei-chen
DNA Dark Matter Detectors: https://arxiv.org/pdf/1206.6809.pdf
Ticker Tape Paper: https://arxiv.org/ftp/arxiv/papers/1306/1306.5709.pdf
Bionumbers: https://bionumbers.hms.harvard.edu/search.aspx?trm=ribosome+coli
Inflation Calculator: https://www.usinflationcalculator.com/
OUTLINE:
0:00 - Expansion Microscopy in 120 seconds
2:12 - Introduction
3:12 - From EE to Biology
6:37 - Transition to Graduate School
9:53 - The Chen Lab
11:17 - What Do You Look for In Undergrads?
13:53 - Working as a Mentor
16:15 - Overview of Expansion Microscopy
26:02 - Does the Exact Expansion Factor Matter?
28:05 - ExMic + Electron Microscopy?
31:11 - Feeling of Discovery as a Grad Student
34:08 - Difficulties Along the Way
35:46 - From Grad School to Chen Lab
39:19 - How are Abundances of Genes Measured?
45:27 - The Cell as a State Machine
53:40 - Where is the ROM?
58:35 - Temporal Genomics and Dynamic Videos
1:07:19 - Overview of Slide Seq
1:19:31 - Are There Enough Tools in This Field?
1:24:00 - Sources of Inspiration
1:26:53 - OpenWetWare
1:33:00 - Advice to Young People
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