America is divided, and it always has been. We're going back to the moment when that split turned into war. This is Uncivil: Gimlet Media's new history podcast, hosted by journalists Jack Hitt and Chenjerai Kumanyika. We ransack the official version of the Civil War, and take on the history you grew up with. We bring you untold stories about covert operations, corruption, resistance, mutiny, counterfeiting, antebellum drones, and so much more. And we connect these forgotten struggles to the ...
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Inhalt bereitgestellt von The Michael J. Fox Foundation for Parkinson’s Research. Alle Podcast-Inhalte, einschließlich Episoden, Grafiken und Podcast-Beschreibungen, werden direkt von The Michael J. Fox Foundation for Parkinson’s Research oder seinem Podcast-Plattformpartner hochgeladen und bereitgestellt. Wenn Sie glauben, dass jemand Ihr urheberrechtlich geschütztes Werk ohne Ihre Erlaubnis nutzt, können Sie dem hier beschriebenen Verfahren folgen https://de.player.fm/legal.
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The news you need to know today — and the stories that will stick with you tomorrow. Plus, special series and behind-the-scenes extras from Here & Now hosts Robin Young, Scott Tong and Deepa Fernandes with help from Producer Chris Bentley and the team at NPR and WBUR.
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The election has been decided, and Donald J. Trump is the United States’ 47th president. With 15 years of experience covering politics, Puck senior political correspondent Tara Palmeri is here to bring you all the latest news and developments from Trump’s second term, including her exclusive reporting and interviews with the smartest political brains to discuss all the latest developments from the front page to behind the scenes in Washington, D.C.
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A handpicked article read aloud from the latest issue of The Economist. Published weekdays from Monday to Thursday. If you’re already a subscriber to The Economist, you’ll have full access to all our shows as part of your subscription. For more information about Economist Podcasts+, including how to get access, please visit our FAQs page here https://myaccount.economist.com/s/article/What-is-Economist-Podcasts.
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Weekly wrap of events of the week peppered with context, commentary and opinion by a superstar panel. Click here to support Newslaundry: http://bit.ly/paytokeepnewsfree Hosted on Acast. See acast.com/privacy for more information.
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Diane Rehm’s weekly podcast features newsmakers, writers, artists and thinkers on the issues she cares about most: what’s going on in Washington, ideas that inform, and the latest on living well as we live longer.
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In August of 1619, a ship carrying more than 20 enslaved Africans arrived in the English colony of Virginia. America was not yet America, but this was the moment it began. No aspect of the country that would be formed here has been untouched by the 250 years of slavery that followed. On the 400th anniversary of this fateful moment, it is time to tell the story. “1619” is a New York Times audio series hosted by Nikole Hannah-Jones. You can find more information about it at nytimes.com/1619pod ...
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Our weekly podcast from Politics Home discussing all the ups and downs in Westminster. Please subscribe and share - and keep up with all the latest news on PoliticsHome.com. Got a question for the team? news@politicshome.com.
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Hosted by CNN's Jake Tapper and Dana Bash, State of the Union features interviews with top newsmakers on politics and policy—covering Washington, the country, and the world.
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The UK Column is an independent news organisation analysing the information war. Operating without financial backing or external investment, we remain free from advertisers, foundations, and political parties, relying solely on support from our audience through memberships and donations.
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<div class="span index">1</div> <span><a class="" data-remote="true" data-type="html" href="/series/on-the-bus-with-troy-vollhoffer">On the Bus with Troy Vollhoffer</a></span>
Troy Vollhoffer, owner and founder of Country Thunder Music Festival, invites the biggest country artists to join him for a one-on-one celebrity interview “On the Bus”. As Troy opens his home, his tour bus, and festival venues to his audience for behind the scenes conversations, he asks exclusive questions, discusses festival do’s and don'ts, and highlights the tracks you will hear on stage at Country Thunder this summer. Guests include Dustin Lynch, Koe Wetzel, Tigirlily Gold, Dierks Bentley, Bailey Zimmerman, Jon Pardi, Ashley McBryde and countless other music industry legends, taking you backstage to share stories of their concerts, their careers, and their entertainment industry journeys. Be ready to be thunderstruck, On the Bus with Troy Vollhoffer.
Tools for Diagnosing and Visualizing Parkinson’s Disease (Webinar Audio)
Manage episode 433826277 series 2456444
Inhalt bereitgestellt von The Michael J. Fox Foundation for Parkinson’s Research. Alle Podcast-Inhalte, einschließlich Episoden, Grafiken und Podcast-Beschreibungen, werden direkt von The Michael J. Fox Foundation for Parkinson’s Research oder seinem Podcast-Plattformpartner hochgeladen und bereitgestellt. Wenn Sie glauben, dass jemand Ihr urheberrechtlich geschütztes Werk ohne Ihre Erlaubnis nutzt, können Sie dem hier beschriebenen Verfahren folgen https://de.player.fm/legal.
Doctors have been using DaTscan brain imaging as a tool to help diagnose the Parkinson’s disease (PD) for more than a decade, but even people who know a lot about the disease often still have questions about its role — and the role of other imaging tools — in diagnosis and care. What’s a DaTscan, and how does it relate to PET, SPECT and MRI? When is a DaTscan or other brain imaging tool used in PD? Are there any risks?
In this audio from our Third Thursdays Webinar, experts and people with PD offer listeners an impromptu course in Brain Imaging 101. You’ll learn to differentiate the different types of imaging used to visualize the brain and how they are used in PD research and care. You’ll also learn the latest in efforts to visualize alpha-synuclein, the protein that misfolds and clumps in Parkinson’s, and what its selective imaging in the living brain will mean for PD clinical trials and care.
Like our podcasts? Please consider leaving a rating or review and sharing the series with your network. https://apple.co/3p02Jw0
Whether you have Parkinson’s or not, you can help move research forward. Join the study that’s changing everything. Find out more at michaeljfox.org/podcast-ppmi.
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Manage episode 433826277 series 2456444
Inhalt bereitgestellt von The Michael J. Fox Foundation for Parkinson’s Research. Alle Podcast-Inhalte, einschließlich Episoden, Grafiken und Podcast-Beschreibungen, werden direkt von The Michael J. Fox Foundation for Parkinson’s Research oder seinem Podcast-Plattformpartner hochgeladen und bereitgestellt. Wenn Sie glauben, dass jemand Ihr urheberrechtlich geschütztes Werk ohne Ihre Erlaubnis nutzt, können Sie dem hier beschriebenen Verfahren folgen https://de.player.fm/legal.
Doctors have been using DaTscan brain imaging as a tool to help diagnose the Parkinson’s disease (PD) for more than a decade, but even people who know a lot about the disease often still have questions about its role — and the role of other imaging tools — in diagnosis and care. What’s a DaTscan, and how does it relate to PET, SPECT and MRI? When is a DaTscan or other brain imaging tool used in PD? Are there any risks?
In this audio from our Third Thursdays Webinar, experts and people with PD offer listeners an impromptu course in Brain Imaging 101. You’ll learn to differentiate the different types of imaging used to visualize the brain and how they are used in PD research and care. You’ll also learn the latest in efforts to visualize alpha-synuclein, the protein that misfolds and clumps in Parkinson’s, and what its selective imaging in the living brain will mean for PD clinical trials and care.
Like our podcasts? Please consider leaving a rating or review and sharing the series with your network. https://apple.co/3p02Jw0
Whether you have Parkinson’s or not, you can help move research forward. Join the study that’s changing everything. Find out more at michaeljfox.org/podcast-ppmi.
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With three new Parkinson’s treatments approved in the last year, there are more options than ever before for people living with the disease. Tune into audio from this Third Thursdays Webinar to hear movement disorder specialists, research experts and a person living with Parkinson’s answer community questions about the new treatments available, explain how therapies make it through FDA approval and share the latest on treatments in the pipeline. Like our podcasts? Please consider leaving a rating or review and sharing the series with your community. https://apple.co/3p02Jw0 The Foundation’s landmark study, the Parkinson’s Progression Marker’s Initiative, also known as PPMI, is recruiting volunteers. Join the study that’s changing everything at michaeljfox.org/podcast-ppmi .…
Movement disorder specialist, lifestyle medicine physician and MJFF Principal Medical Advisor Rachel Dolhun, MD, DipABLM, shares tips on medication management for people at every stage of the disease journey. Like our podcasts? Please consider leaving a rating or review and sharing the series with your community. https://apple.co/3p02Jw0 The Foundation’s landmark study, the Parkinson’s Progression Marker’s Initiative, also known as PPMI, is recruiting volunteers. Join the study that’s changing everything at michaeljfox.org/podcast-ppmi .…
If depression, anxiety or apathy occur as part of a Parkinson’s journey, it can be easy to feel alone, isolated or unsure of what might bring relief. But there are ways to manage these symptoms. Tune into audio from this Third Thursdays Webinar to hear people living with Parkinson’s share their stories of coping with mood changes as well as a movement disorder specialist and psychiatrist discuss pharmacological and non-pharmacological treatments options. Like our podcasts? Please consider leaving a rating or review and sharing the series with your community. https://apple.co/3p02Jw0 The Foundation’s landmark study, the Parkinson’s Progression Marker’s Initiative, also known as PPMI, is recruiting volunteers. Join the study that’s changing everything at michaeljfox.org/podcast-ppmi .…
Movement disorder specialist, lifestyle medicine physician and MJFF Principal Medical Advisor Rachel Dolhun, MD, DipABLM, answers community questions on Parkinson’s and exercise with physical therapist and rehab scientist Cristina Colón-Semenza, PhD. Listen to the audio or watch the video. Like our podcasts? Please consider leaving a rating or review and sharing the series with your community. https://apple.co/3p02Jw0 The Foundation’s landmark study, the Parkinson’s Progression Marker’s Initiative, also known as PPMI, is recruiting volunteers. Join the study that’s changing everything at michaeljfox.org/podcast-ppmi .…
Being a care partner to someone with Parkinson’s disease (PD) can be a shifting and complex role, as symptoms and life circumstances change. And sometimes, this can lead to stress and even burnout for the care partner. Tune into audio from this Third Thursdays Webinar to hear expert panelists discuss how to navigate care partnership, including everyday strategies to de-stress and find supportive community. Like our podcasts? Please consider leaving a rating or review and sharing the series with your community. https://apple.co/3p02Jw0 The Foundation’s landmark study, the Parkinson’s Progression Marker’s Initiative, also known as PPMI, is recruiting volunteers. Join the study that’s changing everything at michaeljfox.org/podcast-ppmi .…
It is widely known that a healthy diet can provide essential nutrients and lead to a multitude of benefits, but growing evidence has highlighted important links between diet, nutrition, and brain health, particularly related to neurodegenerative disease. In this episode, Dr. Puja Agarwal discusses her research investigating the role that diet and nutrition may play in Parkinson’s disease and other neurodegenerative conditions. Evidence from her studies and the work of others suggests that certain diets, including the Mediterranean-DASH Intervention for Neurodegenerative Delay (MIND) diet, are associated with brain health and may have the potential to delay the onset or slow progression of Parkinson's disease or other neurodegenerative conditions. We hear more about her ongoing MJFF-funded research project examining the role of diet in the progression of parkinsonian signs and its association with Lewy body pathologies, as well as future directions for this exciting line of research. Puja is an Assistant Professor in the Department of Internal Medicine at Rush University. Mentioned in this episode: This podcast episode was part of a limited series created by The Michael J. Fox Foundation in 2023 and 2024 for clinicians and researchers in our audience. These episodes provide a deeper dive into exciting new scientific research in Parkinson’s disease, as well as innovative tools and valuable resources, through conversations with a variety of experts in the field. We hope you enjoy the conversation.…
1 Developing a Novel App to Improve Speech Intelligibility in Parkinson's Disease with Gemma Moya-Galé 44:16
Parkinson's disease significantly impacts various aspects of communication, and this can make it challenging for people with the disease to communicate effectively, be understood by others, and engage in social situations. Dr. Gemma Moya-Galé joins this episode to talk about her work on voice and communication in people with Parkinson’s disease. In particular, she discusses a novel app she and her team are developing, with funding from The Michael J. Fox Foundation, to help people with Parkinson’s improve how well their speech is understood. The app uses evidence-based principles from speech therapy and noise-augmented automatic speech recognition to provide speech training and feedback. She also shares her recent research on linguistically and culturally responsive methods for addressing communication challenges in both English- and Spanish-speaking individuals with Parkinson's disease, and how this approach has the potential to improve clinical care. Gemma is an Assistant Professor of Communication Sciences and Disorders, as well as the Director of the Communication, Technology, and Language Diversity Lab at Teachers College, Columbia University. Mentioned in this episode: This podcast episode was part of a limited series created by The Michael J. Fox Foundation in 2023 and 2024 for clinicians and researchers in our audience. These episodes provide a deeper dive into exciting new scientific research in Parkinson’s disease, as well as innovative tools and valuable resources, through conversations with a variety of experts in the field. We hope you enjoy the conversation.…
Understanding the biology of Parkinson’s disease (PD) and turning that knowledge into better treatments is a complex undertaking. In this episode of the award-winning Parkinson’s Science POV series, scientists at The Michael J. Fox Foundation (MJFF) discuss how they are tackling this problem from every angle. Whether it’s using cutting-edge imaging to get a picture of the disease in the brain or working with the community to develop better options to treat walking difficulties, our researchers are collaborating to discover the next wave of treatment options and close in on a cure. Like our podcasts? Please consider leaving a rating or review and sharing the series with your community. https://apple.co/3p02Jw0 Watch our webinar or read our Year in Review at michaeljfox.org . The Foundation’s landmark study, the Parkinson’s Progression Marker’s Initiative, also known as PPMI, is recruiting volunteers. Join the study that’s changing everything at michaeljfox.org/podcast-ppmi .…
1 Increasing Diversity in Research and Addressing Brain Health Inequities with Monica Rivera-Mindt 44:34
Certain populations are disproportionately affected by neurological diseases, including Parkinson's and other neurodegenerative diseases. A lot of work remains to be done to improve brain health outcomes and promote healthy brain aging across the lifespan, particularly for minoritized, underrepresented populations. Including participants from diverse backgrounds in research helps ensure that the results from studies and clinical trials in the field are valid, generalizable, and representative of all individuals affected by these diseases. In this episode, Dr. Monica Rivera-Mindt discusses brain health inequities in neurodegenerative diseases, her work using culturally informed community-engaged research methods to improve representation in research studies, important gaps in the literature, lessons learned from the Alzheimer's Disease Neuroimaging Initiative (ADNI) Diversity Task Force that could be applied in Parkinson's disease research, and more. Monica is Professor of Psychology, Latinx studies, and African and African American studies at Fordham University, and she has a joint appointment as Professor of Neurology at the Icahn School of Medicine at Mount Sinai. She is also a board-certified neuropsychologist. Mentioned in this episode: This podcast episode was part of a limited series created by The Michael J. Fox Foundation in 2023 and 2024 for clinicians and researchers in our audience. These episodes provide a deeper dive into exciting new scientific research in Parkinson’s disease, as well as innovative tools and valuable resources, through conversations with a variety of experts in the field. We hope you enjoy the conversation.…
With two new drugs approved by the FDA, a National Plan signed into law and many advances in our understanding of Parkinson’s disease, 2024 has been a transformative year in Parkinson’s research. Tune into audio from this month’s Third Thursdays Webinar to hear research experts from industry and academia talk with MJFF staff about the latest research on disease biology and emerging therapies. Like our podcasts? Please consider leaving a rating or review and sharing the series with your community. https://apple.co/3p02Jw0 The Foundation’s landmark study, the Parkinson’s Progression Marker’s Initiative, also known as PPMI, is recruiting volunteers. Join the study that’s changing everything at michaeljfox.org/podcast-ppmi .…
1 The Development and Application of the Alpha-Synuclein Seed Amplification Assay with Claudio Soto 37:56
Alpha-synuclein plays a key role in the pathophysiology of Parkinson's disease, and researchers have been investigating this protein as a therapeutic target and also as a potential biomarker for the disease. The alpha-synuclein seed amplification assay, developed by Dr. Claudio Soto and colleagues, leverages the self-replicating nature of the misfolded alpha-synuclein proteins that form aggregates in Parkinson's disease. Amplifying misfolded alpha-synuclein can allow researchers and clinicians to detect the presence of the pathological form of the protein in biospecimens, even when the amount of misfolded alpha-synuclein in a sample is very low. In this episode, Claudio discusses his work in this area and how it has opened the doors for a variety of potential uses of the alpha-synuclein seed amplification assay, including applications in diagnosis, clinical trials, and drug development for Parkinson's disease. This year, Claudio received the 2024 Robert A. Pritzker Prize for Leadership in Parkinson’s Research for his substantial contributions to research and his commitment to mentoring the next generation of scientists in the field. Claudio is the Huffington’s Distinguished University Chair, Professor of Neurology, and Director of the George and Cynthia Mitchell Center for Alzheimer’s Disease and Related Brain Disorders at The University of Texas Medical School in Houston. He is also the Founder, Vice-President, and Chief Scientific Officer at AMPRION Inc. Mentioned in this episode: This podcast episode was part of a limited series created by The Michael J. Fox Foundation in 2023 and 2024 for clinicians and researchers in our audience. These episodes provide a deeper dive into exciting new scientific research in Parkinson’s disease, as well as innovative tools and valuable resources, through conversations with a variety of experts in the field. We hope you enjoy the conversation.…
Each person living with Parkinson’s disease (PD) will have a unique journey with their treatments, including the decision to have deep brain stimulation (DBS), which is a surgical procedure to treat Parkinson’s motor symptoms. While DBS isn’t suitable for everyone, it can be helpful in the right person, and it’s a complex, lifelong choice. And although the experience goes far beyond surgery day, brain surgery often looms large in people’s minds as they are contemplating DBS. In this episode, our expert panelists tackle community-sourced questions on DBS surgery day: what to wear, how loved ones can support, what it feels like to be awake during brain surgery and more. Tune in to hear from two people who have had DBS, a neurosurgeon and a movement disorder specialist and learn more about the realities of surgery day. For more information on deep brain stimulation, download our newly updated, comprehensive guide or check out our webinar at michaeljfox.org . Like our podcasts? Please consider leaving a rating or review and sharing the series with your community: https://apple.co/3p02Jw0 The Foundation’s landmark study, the Parkinson’s Progression Marker’s Initiative, also known as PPMI, is recruiting volunteers. People from all backgrounds with and without Parkinson’s can help move research forward. Join the study that’s changing everything at michaeljfox.org/podcast-ppmi .…
1 An Inside Look at the Edmond J. Safra Fellowship in Movement Disorders with Marcelo Merello and Sergio Castillo-Torres 58:23
To help meet the growing global need for more movement disorders specialists, The Michael J. Fox Foundation created the Edmond J. Safra Fellowship in Movement Disorders in collaboration with longtime partner the Edmond J. Safra Foundation. This program supports the training of movement disorders specialists who will provide expert care and drive advances in Parkinson's research. The program is positively impacting early-career clinician-researchers, as well as the centers where they train. These impacts will continue to grow over the years as more fellows are trained. In this episode, Dr. Marcelo Merello and Dr. Sergio Castillo-Torres share their insights and perspectives as a Fellowship Director and a Fellow in the program, respectively. Marcelo is Director of the Department of Neurosciences and Chief of the Movement Disorders Clinic at the Institute for Neurological Research or Fleni Hospital. He is fellowship Director at Fleni and the University of Buenos Aires. In addition, Marcelo is Principal Investigator with the National Council for Scientific and Technical Research and Professor of Neurodegenerative Diseases at the Pontifical Catholic University of Argentina. Sergio is an Associate Professor in Neurology and Internal Medicine at the Dr. Jose E. Gonzales University Hospital of the Autonomous University of Nuevo Leon. He was an Edmond J. Safra Fellow in Movement Disorders at Fleni Hospital. Visit michaeljfox.org/fellowship to learn more about the Edmond J. Safra Fellowship in Movement Disorders. Mentioned in this episode: This podcast episode was part of a limited series created by The Michael J. Fox Foundation in 2023 and 2024 for clinicians and researchers in our audience. These episodes provide a deeper dive into exciting new scientific research in Parkinson’s disease, as well as innovative tools and valuable resources, through conversations with a variety of experts in the field. We hope you enjoy the conversation.…
Troubles with gait – slow walking, shuffling steps and foot dragging and more – can be symptoms of Parkinson’s. In audio from this Third Thursdays Webinar, our experts explore the robust research efforts underway to understand and treat gait issues, from physical rehab interventions to deep brain stimulation modifications to wearable robots designed to smooth gait. Like our podcasts? Please consider leaving a rating or review and sharing the series with your community. https://apple.co/3p02Jw0 The Foundation’s landmark study, the Parkinson’s Progression Marker’s Initiative, also known as PPMI, is recruiting volunteers. Join the study that’s changing everything at michaeljfox.org/podcast-ppmi .…
Stem cell models derived from patients with Parkinson’s disease are valuable tools that are helping researchers around the world to better understand the underlying causes of neurodegeneration and to develop biomarkers and new therapies. To maximize the potential impacts of these tools, it is critical that they are developed and shared according to the principles of open science. In her interview, Dr. Birgitt Schüle discusses her work developing alpha-synuclein cell lines, challenges and opportunities in the field, and important considerations surrounding open science. She goes in-depth on how the cell lines were developed, characterized, and deposited with the American Tissue and Cell Collection (ATCC) with funding support from The Michael J. Fox Foundation, as well as how these cells can be used to fuel future discoveries. Birgitt is an Associate Professor in the Department of Pathology at Stanford University School of Medicine and Co-Director of the Alzheimer’s Disease Research Center, Neuropathology, and Induced Pluripotent Stem Cell (iPSC) Core. Mentioned in this episode: This podcast episode was part of a limited series created by The Michael J. Fox Foundation in 2023 and 2024 for clinicians and researchers in our audience. These episodes provide a deeper dive into exciting new scientific research in Parkinson’s disease, as well as innovative tools and valuable resources, through conversations with a variety of experts in the field. We hope you enjoy the conversation.…
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The Michael J. Fox Foundation Parkinson's Podcast
In this podcast, four people from different backgrounds have a candid conversation on race, stigma and Parkinson’s. They share their experiences trying to find culturally competent medical professionals, overcoming the barriers to research participation, and communicating with their communities about their diagnosis. And they offer tips and advice on finding empowerment through education and advocacy. Like our podcasts? Please consider leaving a rating or review and sharing the series with your community: https://apple.co/3p02Jw0 The Foundation’s landmark study, the Parkinson’s Progression Marker’s Initiative, also known as PPMI, is recruiting volunteers. People from all backgrounds with and without Parkinson's can help move research forward. Join the study that’s changing everything at michaeljfox.org/podcast-ppmi .…
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The Michael J. Fox Foundation Parkinson's Podcast
1 Developing FLEXISyn to Identify and Measure Changes in Alpha-Synuclein in Parkinson's Disease with Judith Steen 36:16
New qualitative and quantitative tools are being developed to measure and track changes in proteins relevant for neurodegenerative disease, and these tools have the potential to accelerate drug discovery and clinical trials. In this episode, Dr. Judith Steen discusses her work creating novel qualitative and quantitative tools and workflows at the interface of proteomics and transcriptomics, including their novel FLEXI platform. This platform uses targeted, high- throughput quantitative mass spectrometry to isolate, quantify, and identify molecular changes in proteins. She describes her ongoing project, funded by The Michael J. Fox Foundation, to develop FLEXISyn, which aims to track post-translational changes in alpha-synuclein to better understand how the protein becomes dysfunctional and begins misfolding and forming toxic aggregations in Parkinson's disease. Judith is Associate Professor of Neurology at Harvard Medical School, a member of the Harvard Stem Cell Institute, and Director of the Neuroproteomics Laboratory in the F.M. Kirby Neurobiology Center at Boston Children's Hospital. Mentioned in this episode: This podcast episode was part of a limited series created by The Michael J. Fox Foundation in 2023 and 2024 for clinicians and researchers in our audience. These episodes provide a deeper dive into exciting new scientific research in Parkinson’s disease, as well as innovative tools and valuable resources, through conversations with a variety of experts in the field. We hope you enjoy the conversation.…
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The Michael J. Fox Foundation Parkinson's Podcast
Parkinson’s disease brings with it many potential symptoms, including hallucinations (seeing things that are not there) and delusions (believing things that are not true). Not everyone will experience these symptoms and not everyone who does will find them bothersome, but it can be a source of uncertainty and concern for people living with the disease. In audio from this Third Thursdays Webinar, our expert panel discusses navigating life with these symptoms and medication and non-medication strategies to manage them. Like our podcasts? Please consider leaving a rating or review and sharing the series with your community. https://apple.co/3p02Jw0 The Foundation’s landmark study, the Parkinson’s Progression Marker’s Initiative, also known as PPMI, is recruiting volunteers. Join the study that’s changing everything at michaeljfox.org/podcast-ppmi .…
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The Michael J. Fox Foundation Parkinson's Podcast
1 Clinical Applications of Biomarkers and Large-Scale Collaborative Research with Charles Adler 46:21
Substantial research has focused on identifying biomarkers for the diagnosis of Parkinson's disease (PD) as well as monitoring progression of the disease. In developing these biomarkers, it is critical for scientists to consider how the biomarkers will ultimately be used in the clinic and in clinical trials research. In this interview, Dr. Charles (Chuck) Adler shares his perspectives on how biomarkers are currently being used in clinical and research contexts, and what it would take for him to use them more often in clinical practice. He also discusses how groundbreaking collaborative research studies, including the Arizona Study of Aging and Neurodegenerative Disorders and the Parkinson's Progression Markers Initiative (PPMI), are having major impacts on the field. Chuck is Consultant and Professor of Neurology in the Department of Neurology and The Wayne and Kathryn Preisel Professor of Neuroscience Research at the Mayo Clinic Alix School of Medicine at the Mayo Clinic in Arizona. Mentioned in this episode: This podcast episode was part of a limited series created by The Michael J. Fox Foundation in 2023 and 2024 for clinicians and researchers in our audience. These episodes provide a deeper dive into exciting new scientific research in Parkinson’s disease, as well as innovative tools and valuable resources, through conversations with a variety of experts in the field. We hope you enjoy the conversation.…
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The Michael J. Fox Foundation Parkinson's Podcast
1 Investigating Light Therapy For Sleep and Motor Function in People with PD with Beatrix Feigl 41:48
Sleep disturbances, such as insomnia, sleep fragmentation, excessive daytime sleepiness, and REM sleep behavior disorder are common in people with Parkinson's disease (PD). Poor sleep quality can also impact other domains of function, including motor function. Prior research has shown that a type of photoreceptor cell in the retina, called melanopsin cells, provide the main light signals to the brain to initiate sleep, and function of these cells is impaired in PD. Dr. Beatix Feigl and her colleagues developed a novel light therapy intervention that selectively activates the melanopsin photoreceptor cells, and in this episode, she discusses the results of a recent randomized controlled trial evaluating the efficacy of this melanopsin photoreceptor-directed light therapy on sleep and circadian rhythm, as well as motor behaviors. She also discusses her earlier work on melanopsin cells that led to the development of standard measures to assess their function. Beatrix is an Ophthalmologist and an Associate Professor in the School of Biomedical Sciences and Center for Vision and Eye Research, as well as the Faculty of Health, at the Queensland University of Technology. Mentioned in this episode: This podcast episode was part of a limited series created by The Michael J. Fox Foundation in 2023 and 2024 for clinicians and researchers in our audience. These episodes provide a deeper dive into exciting new scientific research in Parkinson’s disease, as well as innovative tools and valuable resources, through conversations with a variety of experts in the field. We hope you enjoy the conversation.…
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The Michael J. Fox Foundation Parkinson's Podcast
Finding the right Parkinson’s treatment plan can be a trial-and-error process. The kind of medication, the dosage, the timing and lifestyle factors are all important pieces of the puzzle. In audio from this Third Thursdays Webinar, our expert panel made up of people living with Parkinson’s disease (PD), a movement disorder specialist and a researcher discuss different medication options, practical tips for finding what works best for you and the latest research on emerging treatments. Like our podcasts? Please consider leaving a rating or review and sharing the series with your community. https://apple.co/3p02Jw0 The Foundation’s landmark study, the Parkinson’s Progression Markers Initiative, also known as PPMI, is recruiting volunteers. Join the study that’s changing everything at michaeljfox.org/podcast-ppmi .…
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The Michael J. Fox Foundation Parkinson's Podcast
Though existing evidence supports that dysfunction in the clearing of cellular debris plays an important role in the development of Parkinson's disease, many unanswered questions remain regarding the mechanisms of the autophagy-lysosomal pathway involved in this process. In particular, research in the field has been limited by a lack of reliable, quantitative tests for monitoring autophagy-lysosome activity. In this interview, Dr. Zhenyu Yue describes his research investigating the cellular and molecular mechanisms for Parkinson's disease and other neurodegenerative diseases, focusing on their work examining the regulation of the autophagy-lysosomal pathway, potential therapeutic targets, and MJFF-funded research that aims to develop sensitive, robust autophagy-lysosome assays to facilitate the discovery of biomarkers for PD using stem cell-derived neurons and biofluids. Zhenyu is the Aidekman Research Professor in the Department of Neurology and Friedman Brain Institute at the Icahn School of Medicine at Mount Sinai. He is also the Director of the Center of Parkinson’s Disease Neurobiology and Director of Basic Research of Movement Disorders at Mount Sinai. Mentioned in this episode: This podcast episode was part of a limited series created by The Michael J. Fox Foundation in 2023 and 2024 for clinicians and researchers in our audience. These episodes provide a deeper dive into exciting new scientific research in Parkinson’s disease, as well as innovative tools and valuable resources, through conversations with a variety of experts in the field. We hope you enjoy the conversation.…
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The Michael J. Fox Foundation Parkinson's Podcast
Research shows mindfulness and meditation can improve some Parkinson’s (PD) symptoms and help people live a better life with the disease, but it can be tricky to put into practice. In this podcast, you’ll hear from people whose lives have been touched by PD and who use mindfulness to reduce symptoms and stress, and from a researcher who is studying how mind-body strategies can be used to treat Parkinson’s. Tune in for practical tips, advice and a guided meditation you can try at home. You can find links to the resources mentioned in the episode on our website: michaeljfox.org/podcast/breathing-through-mindfulness-parkinsons-treatment-tool You can also download our free guide on exercise and Parkinson’s disease, which includes tips for incorporating meditation into your daily routine at michaeljfox.org/exerciseguide Like our podcasts? Please consider leaving a rating or review and sharing the series with your community. https://apple.co/3p02Jw0…
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The Michael J. Fox Foundation Parkinson's Podcast
1 Studying CSF Element Profiles and Tear Fluid as Potential Biomarkers, and Novel and Combined Therapies for PD with Paul Lingor 47:57
Evidence supports that dysfunction in the homeostasis of iron and other elements likely contributes to the pathophysiological mechanisms of Parkinson's disease, but we have yet to develop suitable elemental biomarkers for use in diagnosing and monitoring the progression of Parkinson's disease. Dr. Paul Lingor discusses his work in this area to identify patterns of bioelements in CSF that could serve as PD biomarkers. Beyond CSF, he is also examining tear fluid as a potential biomarker source that is easier to collect. In addition to work on biomarkers, Paul has been involved in developing and evaluating new treatments for Parkinson's disease. In this episode, he discusses an ongoing phase II clinical trial evaluating the ROCK inhibitor Fasudil, as well as research examining combinations of advanced therapies for people with later-stage Parkinson's disease. Paul is Professor of Neurology at the Technical University of Munich and head of the outpatient clinics for motor neuron disease and co-head of the outpatient clinics for Parkinson’s disease. Mentioned in this episode: This podcast episode was part of a limited series created by The Michael J. Fox Foundation in 2023 and 2024 for clinicians and researchers in our audience. These episodes provide a deeper dive into exciting new scientific research in Parkinson’s disease, as well as innovative tools and valuable resources, through conversations with a variety of experts in the field. We hope you enjoy the conversation.…
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The Michael J. Fox Foundation Parkinson's Podcast
The decision-making process around deep brain stimulation (DBS) to treat Parkinson’s motor symptoms can be a complex and emotional journey. People often have questions about when – and whether – to have the procedure and what the experience is like, from the months of evaluation pre-surgery to surgery day to life with the device. In audio from this Third Thursdays Webinar, our panel of people living with Parkinson’s disease (PD) and a movement disorder specialist share their DBS stories and answer audience questions about their choices and experiences. Learn more about deep brain stimulation and download our free guide on our website: https://bit.ly/4cTOT52 Like our podcasts? Please consider leaving a rating or review and sharing the series with your community. The Foundation’s landmark study, the Parkinson’s Progression Markers Initiative, also known as PPMI, is recruiting volunteers. Join the study that’s changing everything at michaeljfox.org/podcast-ppmi .…
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The Michael J. Fox Foundation Parkinson's Podcast
1 Current and Emerging Imaging Biomarkers for Diagnosis and Prognosis of PD and Atypical Parkinsonism with Antonio Strafella 37:57
Identifying reliable biomarkers for the diagnosis and prognosis of Parkinson's disease and atypical parkinsonism would have substantial impacts on clinical trials and clinical practice. A particularly active area of research is the development of novel molecular imaging biomarkers that can be used in combination with common neuroimaging approaches. Dr. Antonio Strafella discusses current practices for using molecular imaging biomarkers in research and in the clinic, the process of developing new biomarkers, as well as promising biomarkers that are in development. He also discusses limitations, implementation challenges, and the potential use of AI to enhance diagnostics in the future. Antonio is the Krembil-Rossy Chair in Molecular Imaging of Neurodegenerative Diseases and Professor in the Department of Medicine within the Division of Neurology at the Toronto Western Hospital (University Health Network, University of Toronto). He also serves as Director of Clinical Research and Translation with the Temerty Faculty of Medicine at the University Toronto, and he is a movement disorder neurologist in the Edmond J. Safra Program in Parkinson’s Disease and Morton & Gloria Shulman Movement Disorders Clinic at the Toronto Western Hospital. Mentioned in this episode: This podcast episode was part of a limited series created by The Michael J. Fox Foundation in 2023 and 2024 for clinicians and researchers in our audience. These episodes provide a deeper dive into exciting new scientific research in Parkinson’s disease, as well as innovative tools and valuable resources, through conversations with a variety of experts in the field. We hope you enjoy the conversation.…
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The Michael J. Fox Foundation Parkinson's Podcast
Just over a year ago, there was a major breakthrough in Parkinson’s disease (PD) research – a tool that could detect abnormal alpha-synuclein protein in the spinal fluid of people living with PD even before onset of symptoms. This discovery is already impacting the ways scientists conduct and think about Parkinson’s research. Tune into this episode of our award-winning “Parkinson’s Science POV” series to learn how researchers are using the test to better understand disease biology and what the future holds. Like our podcasts? Please consider leaving a rating or review and sharing the series with your community. https://apple.co/3p02Jw0 The Foundation’s landmark study, the Parkinson’s Progression Markers Initiative, also known as PPMI, is recruiting volunteers. Join the study that’s changing everything at michaeljfox.org/podcast-ppmi .…
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The Michael J. Fox Foundation Parkinson's Podcast
1 Examining Links Between Environmental Exposure, Poor Olfaction, and Parkinson's Disease with Honglei Chen 47:15
Prior studies have established links between poor olfaction and Parkinson's disease, and impaired sense of smell is a common prodromal symptom of Parkinson's disease. The causes and mechanisms of prodromal neurodegeneration are actively being researched. However, environmental exposure to pesticides or other chemicals may trigger or modify the course of neurodegeneration, potentially leading to the development of Parkinson's disease over time. In this episode, Dr. Honglei Chen shares his research on environmental causes of neurodegenerative diseases, focusing particularly on evidence linking olfaction, environmental exposure, and Parkinson’s disease. Better understanding how environmental factors may contribute (alone or in combination with genetic factors) to the pathogenesis of Parkinson's disease may lead to new approaches to prevent or slow the progression of neurodegeneration. Honglei is the MSU Research Foundation Professor of Epidemiology and Biostatistics at Michigan State University. Mentioned in this episode: This podcast episode was part of a limited series created by The Michael J. Fox Foundation in 2023 and 2024 for clinicians and researchers in our audience. These episodes provide a deeper dive into exciting new scientific research in Parkinson’s disease, as well as innovative tools and valuable resources, through conversations with a variety of experts in the field. We hope you enjoy the conversation.…
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The Michael J. Fox Foundation Parkinson's Podcast
You might be interested in stepping forward for science to play a role in the next breakthrough in Parkinson’s research, but still have questions about how to actually participate. How do you pick the right study for you? How do you balance your life logistics and your medical care considerations? What rights do you have when you participate in a study? In audio from this Third Thursdays Webinar, our panel of people living with Parkinson’s and research experts discuss the practicalities and benefits of volunteering for research. Like our podcasts? Please consider leaving a rating or review and sharing the series with your community. https://apple.co/3p02Jw0 The Foundation’s landmark study, the Parkinson’s Progression Markers Initiative, also known as PPMI, is recruiting volunteers. Join the study that’s changing everything at michaeljfox.org/podcast-ppmi .…
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The Michael J. Fox Foundation Parkinson's Podcast
1 Developing Interventions to Improve Gait and Increase Physical Activity in Parkinson’s Disease with Gammon Earhart 43:06
Gait impairments such as slow speed, small steps, and high variability from step to step are common in people with Parkinson's disease, and these changes begin to occur early in the course of disease. Freezing of gait may develop later for some individuals, and it has been linked to falls and other adverse outcomes. When the quality of walking declines, it can lead to a reduction in the quantity of walking and overall physical activity, which is also related to poorer health outcomes. To prevent this cascade of events, Dr. Gammon Earhart is developing and evaluating interventions to improve gait and increase physical activity in People with Parkinson's disease. In this episode, she discusses how she and collaborators are conducting studies on different approaches, including a mobile health application, self-generated rhythmic cues in the form of singing, and mindfulness training, to improve aspects of walking and physical activity in people with Parkinson's disease. Gammon is Professor of Physical Therapy, Neurology, and Neuroscience, Associate Dean for Physical Therapy, and Director of the Program in Physical Therapy at Washington University School of Medicine in St. Louis. Mentioned in this episode: This podcast episode was part of a limited series created by The Michael J. Fox Foundation in 2023 and 2024 for clinicians and researchers in our audience. These episodes provide a deeper dive into exciting new scientific research in Parkinson’s disease, as well as innovative tools and valuable resources, through conversations with a variety of experts in the field. We hope you enjoy the conversation.…
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