Lp(a), the Little Hellfire Engine That Could (Kill You)

MedEvidence Articles

In this episode, we embark on a journey through the intricate highways of the bloodstream, exploring the fascinating world of lipoproteins. These ingenious packages, comprised of lipids and proteins, navigate the watery terrain of blood, ferrying essential nutrients and molecules like cholesterol to cells throughout the body. But our adventure takes a dark turn as we encounter the menacing Lp(a), a variant of lipoprotein with the potential to wreak havoc on the cardiovascular system. As we navigate the complexities of high Lp(a) levels and their genetic underpinnings, we illuminate the ongoing quest for innovative treatments and the importance of clinical trials in combating this formidable foe. Join us as we embark on this enlightening odyssey through the realm of lipoproteins, shedding light on their mysteries and paving the way for a healthier future.
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References:
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Devaraj, S., Semaan, J. R., & Jialal, I. (2019). Biochemistry, apolipoprotein B. https://europepmc.org/article/NBK/nbk538139

Feingold, K. R. (2024). Introduction to lipids and lipoproteins. Endotext [Internet]. https://www.ncbi.nlm.nih.gov/books/NBK305896/

Kamstrup, P. R., Neely, R. D. G., Nissen, S., Landmesser, U., Haghikia, A., Costa-Scharplatz, M., ... & Nordestgaard, B. G. (2024). Lipoprotein (a) and cardiovascular disease: sifting the evidence to guide future research. European Journal of Preventive Cardiology, zwae032. https://academic.oup.com/eurjpc/advance-article/doi/10.1093/eurjpc/zwae032/7585314

Koschinsky, M. L., Stroes, E. S., & Kronenberg, F. (2023). Daring to dream: Targeting lipoprotein (a) as a causal and risk-enhancing factor. Pharmacological Research, 106843. https://www.sciencedirect.com/science/article/pii/S1043661823001998

Lampsas, S., Xenou, M., Oikonomou, E., Pantelidis, P., Lysandrou, A., Sarantos, S., ... & Siasos, G. (2023). Lipoprotein (a) in Atherosclerotic Diseases: From Pathophysiology to Diagnosis and Treatment. Molecules, 28(3), 969. https://www.mdpi.com/1420-3049/28/3/969

Schmidt, K., Noureen, A., Kronenberg, F., & Utermann, G. (2016). Structure, function, and genetics of lipoprotein (a). Journal of lipid research, 57(8), 1339-1359. https://www.jlr.org/article/S0022-2275(20)35208-1/fulltext