One In Six Billion podcast

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Inhalt bereitgestellt von Andrew Hattersley and Maggie Shepherd, Andrew Hattersley, and Maggie Shepherd. Alle Podcast-Inhalte, einschließlich Episoden, Grafiken und Podcast-Beschreibungen, werden direkt von Andrew Hattersley and Maggie Shepherd, Andrew Hattersley, and Maggie Shepherd oder seinem Podcast-Plattformpartner hochgeladen und bereitgestellt. Wenn Sie glauben, dass jemand Ihr urheberrechtlich geschütztes Werk ohne Ihre Erlaubnis nutzt, können Sie dem hier beschriebenen Verfahren folgen https://de.player.fm/legal.

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Jeff Kerr: Our First Amendment Right to Receive Communications (from Monkeys) 30:14

vor 12 Tagen30:14

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30:14

"It is a scientific fact that these macaques, like all other primates, including humans, are communicating. They communicate in much the same way we do - facial expressions, vocalizations, body postures, those kinds of things." - Jeff Kerr Jeff Kerr is PETA foundations Chief Legal Officer. I asked him to come on the show to talk about one of PETA’s current lawsuits against the National Institutes of Health (NIH) and Nathional Institute of Mental Health (NIMH). PETA is arguing that the monkeys being tested on in a government run facility are capable of communication (or “are communicating”). And that we have a constitutional right under the First Amendment to receive their communications. This could be a game changer in allowing us to see what’s really going on in labs that are funded by taxpayer money, and which have so far been censored from public view. PETA’s lawsuit follows years of NIH’s attempts to deny Freedom of Information requests banning PETA executives from its campus and illegally censoring animal advocates’ speech on NIH’s public social media pages. Through the lawsuit, PETA is seeking a live audio-visual feed to see and hear real-time communications from the macaques who have been kept isolated, used in fear experiments, and had posts cemented into their heads. Anthropologists and other scientists have studied macaque and other primate communications for decades and know that the monkeys communicate effectively and intentionally through lip smacking, fear grimaces, body language, and various cries and sounds—all of which constitute speech under the law. Primatologists can analyze that speech on a deeper level to share their stories with the world.…

One in Six Billion

Serie-Home•Feed

A podcast about diabetes and genes hosted by Andrew Hattersley and Maggie Shepherd.

42 Episoden

#Fitness #Andrew Hattersley And Maggie Shepherd #Andrew Hattersley #Maggie Shepherd #Medicine

One in Six Billion

updated vor 6 Stunden

Serie-Home•Feed

A podcast about diabetes and genes hosted by Andrew Hattersley and Maggie Shepherd.

42 Episoden

#Fitness #Andrew Hattersley And Maggie Shepherd #Andrew Hattersley #Maggie Shepherd #Medicine

Alle Folgen

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Special episode 7. Maggie Shepard (part 2). Inspirational nurse researcher and educator 28:59

vor 6 hours28:59

28:59

Professor Maggie Shepherd reflects back on her career and how she made the massive steps from being a clinical nurse to becoming a nationally leading researcher and educator. Send us a text

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Special episode 6. Andrew Hattersley (part 2). Building the Exeter diabetes research team 29:54

vor 14 Tagen29:54

29:54

Andrew Hattersley describes how teamwork and mutual support has helped the Exeter diabetes research team expand and flourish over the past 30 years Send us a text

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Series 3 Episode 16. Grace Bervoets and Amanda Stride. Cystic Fibrosis related Diabetes 32:24

vor 28 Tagen32:24

32:24

Grace Bervoets talks about living with cystic fibrosis and cystic fibrosis related-diabetes. Amanada Stride, who works as a diabetes consultant helping people with cystic fibrosis related-diabetes, explains the many challenges of this unusual type of diabetes. Send us a text

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Series 3 Episode 15. Tom Staniford. MDP syndrome 42:58

vor 6 weeks42:58

42:58

Tom Staniford talks about living with the MDP syndrome, an extremely rare genetic condition. MDP syndrome includes Mandibula hypoplasia, Deafness, and Progeroid features amongst its widespread features. Tom developed Type 2 diabetes as a teenager because of a loss of fat under the skin (lipodystrophy) despite being very thin and active. Tom has used his communication and media skills to help other people with MDP syndrome get diagnosed and receive the right care. Send us a text…

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Series 3 Episode 14: Farah O'Regan and Matt Johnson. Down syndrome and very young onset diabetes 33:26

vor 8 weeks33:26

33:26

Farah O'Regan talks about how her son who had Down syndrome and a severe congenital heart condition needing surgery diagnosed in pregnancy and then developed Type 1 diabetes on day 2 of life. In early childhood he was diagnosed with 2 more autoimmune conditions, coeliac disease and hypothyroidism. Researcher Matt Johnson explains his research which has established that Down syndrome directly results in very early-onset autoimmune diabetes. Send us a text…

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Series 3 Episode 13. Abby Gardener and Tim Barrett. Wolfram syndrome / WFS1 Spectrum disorder 34:53

vor 10 weeks34:53

34:53

Abby Gardener describes how she was diagnosed with Wolfram syndrome after developing both insulin-treated diabetes and diabetes insipidus (when the urine cannot concentrate) and how this has impacted her life. Professor Tim Barrett talks about how, throughout his career, he has been researching and providing care for patients with Wolfram syndrome. He explains that it is now recognised that there are a range of features that can result from the genetic change (WFS1 spectrum disorder) and that not every patient will have all the severe changes previously described in Wolframs syndrome. Send us a text…

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Series 3 Episode 12. Cassi Connelly. Familial Partial Lipodystrophy 36:01

vor 12 weeks36:01

36:01

Cassi Connelly talks about her experience of having familial partial lipodystrophy characterised by a loss of fat and muscular appearance of her arms and legs. She had multiple medical problems including diabetes for decades before the diagnosis of familial partial lipodystrophy was finally confirmed by a genetic test. Her treatment is now better tailored to her needs. Send us a text…

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Series 3 Episode 11. Rebecca Goodman. Living well with Bardet-Biedl syndrome. 29:14

vor 14 weeks29:14

29:14

Rebecca Goodman talks to Andrew and Maggie about what it is like to grow up with Bardet-Biedl syndrome. Features of Bardet-Biedl syndrome include extra fingers and toes, progressive blindness, kidney problems, obesity due to an uncontrolled appetite, insulin resistance and diabetes. Despite this long list of medical issues Rebecca lives independently and enjoys a full and fun life. Send us a text…

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Special episode 5. John Dennis. Research breakthrough in Type 2 diabetes treatment. 24:01

vor 16 weeks24:01

24:01

We talk to John Dennis, a data science researcher working in the University of Exeter. He used data from 1 million people with Type 2 diabetes to discover how the clinical characteristics of a patient alter the glucose lowering with different treatments. John’s 5 drug model, published in the Lancet in late February 2025, uses simple clinical information to identify, for the first time, the best glucose lowering treatment for a patient. The model selected best treatment lowers the glucose most, doubles the time before another medication is needed and reduces long term complications of diabetes. See www.1in6b.com for more details. Send us a text…

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Series 3 Episode 10. Julie Reynolds and Kash Patel. Maternally inherited diabetes and deafness 33:05

vor 18 weeks33:05

33:05

Julie Reynolds describes how she gradually lost her hearing in her 30’s and developed diabetes in her 40’s these 2 conditions also developed in in her mother, her children and other maternal relative. This led to a diagnosis of maternally inherited diabetes and deafness that results from a change in the mitochondrial DNA. Kash Patel explains the science between diabetes, deafness and a maternal inheritance and why there is a lot of variation in the presence and severity of clinical features Send us a text…

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Series 3 Episode 9. Ru Kovvuri and Rhian Clissold Cognitive and medical impacts of the HNF1B deletion syndrome 37:44

vor 20 weeks37:44

37:44

Ru Kovvuri explains about her battle to get a diagnosis and support for her daughter who had multiple medical problems and learning difficulties as a result of a deletion of the HNF1B gene. Rhian Clissold discusses her research to improve the diagnosis of the HNF1B syndrome and recognise the associated learning difficulties seen with loss (deletion) but not the spelling mistakes (mutations) in the HNF1B gene. Send us a text…

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Series 3 episode 8. HNF1Beta syndrome: kidney disease, diabetes, liver dysfunction and much more 48:13

vor 22 weeks48:13

48:13

Grant King talks about his diagnostic journey where his low birth weight, childhood kidney disease, diabetes, liver dysfunction and infertility were at 32 years finally recognised as all being due to a change in the HNF1Beta gene. Dr Coralie Bingham explains how her research during her PhD in Exeter led to HNF1Beta being established as the commonest cause of inherited kidney disease and all the key parts of the HNF1Beta syndrome being recognised. Send us a text…

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Series 3 episode 7. Natalie Raphael and Alice Hughes Testing fetal genetics using mum’s blood in Glucokinase pregnancy 37:05

vor 24 weeks37:05

37:05

Natalie Raphael was diagnosed as having glucokinase MODY at the end of her first pregnancy. In her second pregnancy she had a recently introduced blood test that showed her fetus had not inherited her change in the glucokinase gene so was at risk of growing large. As a result of this she was given long-acting insulin to lower her glucose. Alice Hughes is the researcher who did the key study that proved the new blood test was both practical and accurate in glucokinase pregnancy. Send us a text…

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Series 3 episode 6. Gill Preston, Gill Spyer, and Ali Chakera The challenge of diagnosing and managing glucokinase MODY in pregnancy 37:38

vor 26 weeks37:38

37:38

It was a great surprise for Gill Preston, who was active and slim, when she was diagnosed with gestational diabetes in her first pregnancy. Her raised fasting glucose did not come down with tablets or insulin. Luckily she met Andrew Hattersley in the diabetes pregnancy clinic, who recognised she had glucokinase MODY. Gill Spyer, working for her PhD as a research doctor showed that in glucokinase pregnancy the size of the baby depended on whether they inherited the genetic change from the mother and was not altered by insulin treatment. When the baby had the mutation it would grow normally and no treatment of the mother was needed. Ali Chakera continued research into glucokinase pregnancy; his research showed that slim women ( BMI <25) with a raised fasting glucose of above 5.5mmol/l had a 1 in 3 chance of having GCK MODY and should be tested. He also looked into genetic testing the fetus directly rather than trying to infer from fetal growth on ultrasound. Send us a text…

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Series 3 episode 5. Andrew Lotery and Amanda Stride: Glucokinase MODY – a mildly raised fasting glucose for life that should not be treated 32:38

vor 28 weeks32:38

32:38

In this episode we talk to Andrew Lotery about how he was found to have a raised fasting glucose on an insurance medical. He was treated as Type 2 diabetes but he questioned this as he was young. slim and physically fit. A chance reading of a research funder’s newsletter led him to the Exeter team and a diagnosis of glucokinase MODY. Amanda Stride worked as a research registrar in Exeter. She showed that in glucokinase MODY the fasting glucose was raised from birth and remained stable and regulated throughout life with treatment not changing the blood glucose. Anna Steele showed in her PhD that patients with glucokinase MODY did not get complications affecting the eye or kidney even after 50 years of raised glucose. So in glucokinase MODY treatment with insulin or tablets is not needed and does not work; patients should be discharged and not followed up. Send us a text…

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Series 3 episode 4. Janette and Alice: Big babies with dangerously low blood sugars in HNF4A MODY 33:54

vor 30 weeks33:54

33:54

In this episode we talk to Janette and her daughter Alice who were both correctly diagnosed with HNF4A MODY having been initially told they had Type 1 diabetes. The diagnosis not only allowed them to stop insulin but also explained the mystery of two of Jeanette’s children that were born as large babies and collapsed soon after birth with low blood sugar. Andrew explains how it was discovered that babies that inherited the HNF4A genetic change were on average over 800g heavier and were at high risk of low blood glucose around birth Send us a text…

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Series 3 episode 3. Mary Lee and Ewan Pearson: Finding the best treatment for HNF1A MODY 27:48

vor 32 weeks27:48

27:48

Mary Lee was thought to have Type 1 diabetes for over 3 decades; she was finally diagnosed with HNF1A MODY and was able to stop her insulin injections and get excellent blood sugar control with a sulphonylurea tablet. We hear from Ewan Pearson how sulphonylurea tablets were found to be excellent glucose lowering treatment when Andrew’s clinical observations of his HNF1A MODY patients were followed up by Ewan with a clinical trial. Send us a text…

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Series 3 episode 2. Kevin Colclough and Bev Shields Making sure the right patients get the right genetic test for MODY 26:25

vor 34 weeks26:25

26:25

Kevin Colclough describes how the genetic testing in diabetes has improved over the 2 decades he has worked in the Exeter NHS diagnostic lab. His work means now over 60 types of single gene diabetes are looked for in one sequencing test. Bev Shields talks about how she developed the amazing MODY calculator that uses common clinical characteristics to work out how likely a person with diabetes is to have maturity onset diabetes of the young (MODY). Send us a text…

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Series 3 episode 1. Mary Humphries: The doctor didn’t listen! A delayed diagnosis of MODY 29:01

vor 36 weeks29:01

29:01

Mary Humphries tells how her son Dan was diagnosed with diabetes aged 16 and it was assumed he had type 1 diabetes and treated with insulin. On insulin he had terrible problems with low blood sugars frequently losing consciousness and not managing to concentrate at school or at home. Mary was very worried that he was getting worse on the insulin and asked about genetic tests because she had recently been diagnosed with Type 2 diabetes and there was diabetes in all generations of her family. She was not listened to; the insulin was continued, and Dan got worse. Searching the internet for answers she found the Exeter diabetesgenes.org website which led her to talking to Andrew and Maggie. They were able to rapidly diagnose that this was Maturity-onset Diabetes of the Young (MODY), subtype HNF1A . with a genetic test. Maggie helped Dan to stop his insulin and get excellent control on a quarter of the sulphonylurea tablet called gliclazide. Dan rapidly improved off the insulin and passed his A levels with flying colours going to Bristol where he achieved his life’s ambition to become a large animal vet. Send us a text…

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Series 2 episode 9. Nick Thomas. Type 1 diabetes in the older adult 24:04

vor 38 weeks24:04

24:04

Dr Nick Thomas talks about Type 1 diabetes in the older adult. In an iconoclastic study he showed most cases of Type 1 diabetes occur in adults rather than children. In older adults it is very hard to recognise as 98-99% of people with diabetes have Type 2 diabetes. Older adults with Type 1 diabetes have just as rapid a decline in their own insulin and need all the expert care offered to children. Send us a text…

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Series 2 episode 8. Simon Goode and Angus Jones. Diagnosing Type 1 diabetes is difficult in older adults 38:57

vor 40 weeks38:57

38:57

Simon Goode was diagnosed with Type 2 diabetes aged 28. He explains how it took 6 months of feeling unwell before it was realised he had Type 1 diabetes instead. Exeter Professor, Angus Jones, has done research showing that mistakes in the diagnosis Type of 1 diabetes are common in the older adult and offers solutions to help doctors get the diagnosis right. Send us a text…

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Series 2 Episode 7. Jean Claude Katte. Type 1 Diabetes in Africa: different in so many ways. 35:45

vor 42 weeks35:45

35:45

Dr Jean Claude Katte explains how in Sub Saharan Africa diagnosis, treatment and monitoring of Type 1 diabetes in children and young adults is so much harder than in Europe. He discusses with Maggie and Andrew his own exciting research that has shown that around 60% of African children with diabetes do not have the typical autoimmune Type 1 diabetes seen in over 90% of children with diabetes in Europe. Jean Claude aims to do more research to discover what causes this new cause of severe young-onset diabetes in Sub Saharan Africa. Send us a text…

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Series 2 episode 6. Mendy Korer and Matt Johnson. Type 1 diabetes in very young children: a massive challenge for families and scientists 47:35

vor 44 weeks47:35

47:35

We hear from Mendy Korer about the enormous challenges of living with a child who was diagnosed with Type 1 diabetes aged 11 months. Matt Johnson, a research fellow in Exeter talks about his exciting work understanding what makes the immune system destroy the insulin making beta-cells in very young children. Send us a text…

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Series 2 Episode 5. Richard Oram . Genius genetics improves diagnosis and prevention of Type 1 diabetes 29:58

vor 46 weeks29:58

29:58

Professor Richard Oram had the innovative idea of turning complex analysis of the genetic changes into a single number that estimate the likelihood of developing Type 1 diabetes. He explains to Andrew and Maggie how this has helped diagnosis of Type 1 diabetes and is being used around the world in studies aiming to prevent or delay diabetes in children. Send us a text…

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Series 2 Episode 4. Partha Kar. The super hero who made sure Type 1 diabetes technology was for everyone 40:51

vor 48 weeks40:51

40:51

Professor Partha Kar has made sure the technical advances in measuring blood sugar are available to everyone living with Type 1 diabetes in the UK. Partha had to overcame massive hurdles to make sure the technology was not just available to a privileged few. He discusses with Maggie and Andrew his inspirational leadership style and philosophy that have helped him to move mountains in the NHS. Vote for One in Six Billion in the British Podcast Awards: https://www.britishpodcastawards.com/voting Send us a text…

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Series 2 Episode 3. Jean Dudderidge and Jill Epton. Living with Type 1 diabetes for over 50 years. 33:06

vor 50 weeks33:06

33:06

Jean Dudderidge and Jill Epton talk about what it has been like to live with Type 1 diabetes for over 50 years. They discuss the massive advances in the measurement of blood sugar over the decades and how they now benefit greatly from continuous glucose monitoring. Send us a text

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Series 2 Episode 2. Moira Murphy and Mark McCarthy. Defining the genetic susceptibility to Type 2 diabetes 45:01

vor 52 weeks45:01

45:01

Moira Murphy and Mark McCarthy talk about how a unified UK team of scientists came to be world leaders in decoding the genetic susceptibility to Type 2 diabetes. Send us a text

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Series 2 Episode 1. Tim Frayling and Rachel Freathy. Finding the Fat gene 24:52

vor 1 year24:52

24:52

We talk to Tim Frayling and Rachel Freathy about how they discovered the “Fat gene”. Working with Oxford, the Exeter team showed a genetic change near FTO predisposed to obesity. This was the first and largest common genetic change altering weight. Send us a text

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Special episode 4. Tim Frayling – From PhD student to internationally famous polygenic team leader 31:45

vor 1 year31:45

31:45

In this special episode, we hear from Professor Tim Frayling who was Andrew and Sian’s first PhD student in 1995. He rapidly became the head of the analysis for the genetic susceptibility for Type 2 diabetes. His leadership has made Exeter an international leader in polygenic trait genetics. Send us a text…

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Special episode 3. Sian Ellard – establishing a world leading genetics lab from scratch 42:30

vor 1 year42:30

42:30

In this special episode, we hear from Professor Sian Ellard who, like Andrew and Maggie, started in Exeter in 1995. Sian set up the Exeter molecular genetics laboratory from scratch. Through Sian’s leadership, this laboratory became world leading for both research and NHS diagnostic testing. Send us a text…

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