Welcome to American Optimist hosted by Joe Lonsdale, entrepreneur, investor, and founder of four multi-billion dollar companies and other mission-driven organizations. American Optimist is an alternative to the fear, cynicism, and zero-sum thinking in mainstream media. Learn from the innovators and leaders who are solving our nation’s most pressing challenges -- and doing it in a way that will lift everyone up. Hope should dominate our discourse, and American Optimist will show you why.
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Psychedelic Medicine, Value-Based Care & Why Medical School Is Broken with Sebastian Caliri
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Sebastian Caliri is Partner at 8VC with a focus on healthcare investing. Previously, Sebastian spent four years at Palantir where he was responsible for growing its commercial healthcare business. In this episode, Sebastian diagnoses the core problems in U.S. healthcare and explains why traditional fee-for-service care misaligns incentives, resulti…
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The Secrets to Building Great Products with Tony Fadell, Creator of the iPod, iPhone, & Nest Thermostat
38:47
38:47
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38:47
Tony Fadell is one of the great engineers, designers, and business leaders of our time, responsible for creating the iPod, iPhone, and Nest Thermostat. He runs the investment firm Future Shape and recently released his memoir titled “Build: An Unorthodox Guide to Making Things Worth Making." In this episode, he discusses the lessons he learned at G…
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Zach Latta: Building Hack Club & Inspiring the Next Generation of Coders
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31:10
Joe Lonsdale sits down with Zach Latta, Founder of Hack Club, a non-profit network of high school coding clubs with over 15,000 members worldwide. At age 15, Zach helped design one of the most popular apps in the world. At 16, he dropped out of high school to become a programmer before founding Hack Club. He then received a Thiel Fellowship and dec…
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Gene Berdichevsky and Sila’s Game-Changing Battery Technology
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30:55
Gene Berdichevsky is the co-founder and CEO of Sila, a next-gen battery technology company. Previously, he was the seventh employee at Tesla, where he served as Principal Engineer on the Roadster battery and led the development of the world’s first mass-produced lithium-ion car battery. In this episode, he explains how Sila's new battery chemistry …
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Reprogramming Cells, Decentralizing Pharma, and Understanding the Biotech Revolution.
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46:06
Francisco Gimenez is Partner at 8VC and focuses on Bio-IT investments. He received his Ph.D. from Stanford in Biomedical Informatics and B.S. in Electrical Engineering and Computer Sciences from UC Berkeley. In this episode, Francisco explains how breakthroughs in AI, gene editing, and cell therapies converged to jumpstart a new age in biology. He …
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The New Age of Nuclear: Oklo’s Amazing Small Reactor That Reuses Nuclear Waste
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41:34
Jacob DeWitte is the Co-Founder and CEO of Oklo, a nuclear energy startup building small advanced reactors that can reuse spent fuel from conventional reactors. In this episode, DeWitte explains how the regulatory state has stymied new reactor designs for decades, and how he's working to break through and bring game-changing nuclear power technolog…
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Former Defense Secretary Mark Esper: Why Russia’s Invasion Is Failing & How to Bring More Innovation to the Pentagon
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32:56
Dr. Mark Esper served as the U.S. Secretary of Defense from 2019 to 2020 and Secretary of the Army from 2017 to 2019. He's currently the Distinguished Chair of the Modern War Institute at West Point and sits on the Board of Directors of Epirus [a defense startup co-founded by Joe]. His forthcoming memoir is titled "A Sacred Oath: Memoirs of a Secre…
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Free Housing Won’t Solve Homelessness. Judge Glock Explains What Will.
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45:04
Judge Glock is the Director of Research and Policy at the Cicero Institute and an expert on housing and homelessness in the U.S. In this episode, Glock dissects the root causes of America's affordable housing shortage and explains how the right incentives can jumpstart development and bring down home costs for working-class families. He also expose…
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How the Renaissance Sparked an Entrepreneurial Explosion with Jeannette zu Fürstenberg
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44:10
Dr. Jeannette zu Fürstenberg is Co-Founder and General Partner of “La Famiglia”, a Berlin-based Venture Capital fund, and holds a Ph.D. in Philosophy and Entrepreneurship from the Free University of Berlin. She’s also a princess of one of Europe’s oldest royal families by marriage, as well as a thoughtful leader in the innovation and business world…
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How to Take on Big Healthcare & Other Entrenched Interests and Win with Jared Meyer
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35:06
Jared Meyer is the Executive Director of Cicero Action. In this episode, Jared discusses how special interests stifle competition and why Cicero Action is using the special interests' playbook against them to promote innovative, bottom-up reforms. He explains the government affairs strategy that creates real policy changes in states across the coun…
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Unlearning Race and Restoring Liberalism with Thomas Chatterton Williams
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39:00
Thomas Chatterton Williams is a writer, cultural critic, fellow at the American Enterprise Institute, and author of two critically-acclaimed books on race in America, most recently "Self-Portrait in Black and White: Unlearning Race." In this episode, he discusses the dangers of Critical Race Theory and how to move beyond race-first, collectivist mi…
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Hayes Barnard Is Revolutionizing Solar Tech & Green Housing
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34:27
Hayes Barnard is the Founder and CEO of GoodLeap, one of the fastest-growing and largest financial technology companies in the renewable energy sector. In 2008, Barnard founded Paramount Solar, which was later acquired by SolarCity and then Tesla. Barnard discusses his role on the leading edge of America's solar energy expansion and what he learned…
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Fast Grants, Faster Science, and Reviving a Culture of Innovation with Tyler Cowen
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36:54
Tyler Cowen is a professor, best-selling author, blogger, podcaster, and one of the most influential economists of this generation. In the early days of the pandemic, Cowen launched the Fast Grants program, which funded COVID-related science in less than 48 hours -- a remarkable feat in the medical sector. He discusses his efforts to accelerate inn…
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Building a New World-Class University with University of Austin President Pano Kanelos
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Pano Kanelos is the President of the University of Austin (UATX), the most ambitious new university venture in America in decades. Recognizing the plight of America's higher education system, Pano stepped down as the President of St. John's College to build a new institution rooted in the pursuit of truth, open inquiry, and educating the next gener…
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Former UN Ambassador Kelly Craft: How to Deter Russian Threats to Ukraine & Hold China Accountable
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44:42
Ambassador Kelly Craft is a businesswoman, philanthropist, and former diplomat who served as U.S. ambassador to the United Nations from 2019 to 2021 and U.S. ambassador to Canada from 2017 to 2019. She played an integral role in shaping major foreign policy decisions and achievements, such as the landmark Abraham Accords and the USMCA trade agreeme…
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Charles Koch Explains How His Love of Philosophy Built One of America’s Most Successful Companies
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41:23
Charles Koch, Chairman and CEO of Koch Industries, is one of the great business minds of our time. He grew a small engineering firm from $21 million in revenue to over 10,000 times the revenue. Yet in both his business and philanthropic work, he is first and foremost a philosopher. Koch explains how thinkers such as Abraham Maslow and Joseph Schump…
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How to Defeat Special Interests & Cronyism with Florida’s Speaker of the House Chris Sprowls
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32:06
Chris Sprowls is the Speaker of the Florida House of Representatives. Under his leadership, Florida has set itself apart as one of the most innovative state legislatures in the country, slashing regulations that prop up entrenched interests and injecting true competition into the marketplace. We discuss his strategy for successfully combatting cron…
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Are Billionaires Bad? A Friendly Debate Over Income Inequality and Big Tech with Rep. Ro Khanna
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34:47
Congressman Ro Khanna is the Democratic Congressman from California’s 17th District, which covers large swaths of Silicon Valley. A self-described "progressive capitalist," Khanna bucks the current political norms and works to advance meaningful bipartisan legislation. In this episode, we debate income inequality, wealth taxes, and other hot-button…
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The Power of Suffering & Adversity with ”Adventure Capitalist” Dhani Jones
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38:57
Dhani Jones spent 11 seasons in the NFL as a middle linebacker, the linchpin of the defensive unit. Since then, he has become a leader in other arenas: hosting TV shows, launching charities, and investing in startups. His passion is bringing out the best in others. In this episode, he pushes back against the notion of lowering standards to minimize…
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Forget Free College —This Texas College Is the Future of Higher Ed
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31:36
Mike Reeser and Michael Bettersworth are the Chancellor and Chief Innovation Officer, respectively, at Texas State Technical College (TSTC). In 2014, TSTC became the FIRST college in the country to fully align its public funding with its students' future earnings. Since then, graduates have seen their earnings increase over 100 percent! Their succe…
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How to Fix Dysfunctional Government with Esper CEO Maleka Momand | Season 2 | Episode 19
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Maleka Momand is the co-founder and CEO of Esper, a technology platform that transforms how governments oversee the regulatory process. In recent decades, the size of the administrative state has exploded. Yet, many regulators still operate via Word, Excel, and, in some cases, pen and paper! This has led to a lack of transparency and accountability…
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Directed Energy, Force Fields, and the Future of Defense Tech with Epirus Co-Founder Bo Marr | Season 2 | Ep 18
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Over the past few decades, the U.S. military’s long-held advantages have waned. Today, we are reliant on outdated technologies and in jeopardy of falling behind China. Bo Marr, the co-founder and Chief Technology Officer of Epirus, is bucking the trend. Marr and his team invented the world’s most powerful phased array, Leonidas, that can disable dr…
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How to Fix America’s Division with KIND Bar Founder Daniel Lubetzky
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Daniel Lubetzky is the founder of Peaceworks, the OneVoice Movement, and the multi-billion dollar snack company KIND. The son of a Holocaust survivor, Lubetzky’s upbringing inspired him to use business to bridge cultural and economic divides. In this episode, he explains America’s unique role in the world and why we must work together to repair our…
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Maureen Hillenmeyer: Discovering New Life-Saving Drugs from the Natural World | Season 1| Ep 16
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Maureen Hillenmeyer is the Founder and CEO of Hexagon Bio, a cutting-edge biotech company whose mission is to harvest new drugs and cures from the natural world, beginning with fungi. In 1928, Sir Alexander Fleming’s accidental discovery of penicillin launched a new age of antibiotics derived from fungi. However, the process of discovery was slow a…
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Whole Foods Founder & CEO John Mackey: Conscious Capitalism and Repairing America‘s Division | Season 1 | Ep 15
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In 1978, John Mackey co-founded his first natural foods store in Austin, Texas with only $45,000. Two years later, he and his business partners launched the first Whole Foods Market, which quickly became the nation's fastest-growing organic grocery store. In 2017, Amazon acquired the company for over $13 billion. In this episode, the Whole Foods Fo…
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Jake Kloberdanz: Cause-Centric Commerce and the Art of Award-Winning Winemaking | Season 1 | Ep 14
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Jake Kloberdanz is the CEO and Founder of ONEHOPE Wine, an award-winning vineyard located in the heart of Napa Valley. What sets ONEHOPE apart is its unique business model: every bottle of wine sold helps fund a charitable organization. Kloberdanz is a champion of cause-centric commerce, and to date, ONEHOPE has donated over seven million dollars t…
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Sal Churi, Keri Findley, and Wesley Chan: Innovators Changing Our World Right Now | Season 1 | Ep 13
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43:44
This week's episode features three talented and successful innovators behind many game-changing technologies and companies. First is Sal Churi, a former law professor who is now general partner at Trust Ventures -- an Austin-based venture capital firm. Churi helps founders overcome the collision points of innovation and regulation, and explains how…
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Former D.C. Mayor Adrian Fenty: Courage, Accountability, Better Schools, and Safer Cities | Season 1 | Ep 12
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Adrian Fenty is currently a founding managing partner at MaC Venture Capital, a former advisor at Andreessen Horowitz, and served as the Mayor of Washington, D.C. from 2007-2011. During his tenure as Mayor, he took on special interests and the teachers' unions, fought for accountability in government and greater opportunities for children while als…
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Niall Ferguson: Why Civilizations Rise & Fall | Season 1 | Ep 11
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Niall Ferguson is a renowned historian, Senior Fellow at the Hoover Institution, and prolific author of more than a dozen best-selling works on economics, culture, and politics. His newest book, "Doom: The Politics of Catastrophe,” examines how our leaders and societies have dealt with disasters, including pandemics, and how we must learn from the …
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Balaji Srinivasan: Bitcoin, China, the "Woke" Mob, and the Future of the Internet | Season 1 | Episode 10
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Balaji Srinivasan is a bold and forward-thinking writer, investor, and entrepreneur, who was formerly the Chief Technology Officer of Coinbase and general partner at Andreessen Horowitz. Currently, he's launching innovative ventures, such as his 1729 Project, while also advocating for cryptocurrency and the larger decentralized finance movement. In…
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NFL Legend Ronnie Lott: Grit, Leadership, and What America Means to Him | Season 1 | Episode 9
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Ronnie Lott is an NFL Hall of Famer, four-time Super Bowl champion, and one of the greatest defensive players of all time. But his impact and legacy off the field are equally impressive: He's a successful businessman, philanthropist, and community leader who has mentored and shaped the lives of underserved youth across three decades. In this episod…
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Rt. Hon. Stephen Harper: Rejecting Wokeness, Addressing China, and Defending Western Values | Season 1 | Ep 8
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39:05
From 2006 to 2015, the Right Honorable Stephen Harper served as the 22nd Prime Minister of Canada. His premiership confronted challenges ranging from a global recession to the war against ISIS, but his smart and courageous leadership increased Canadian prosperity and bolstered security. Small businesses surged, while tech hubs from Waterloo to Toro…
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Sujay Jaswa: Billion Dollar Wins -- and Losses -- and Solving Silicon Valley's #1 Problem | Season 1 | Ep 7
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37:20
How do you transform a startup into a household name? Ask Sujay Jaswa. When he joined Dropbox in 2010, the company had 16 million users. By the time he left in 2015, hundreds of millions of people relied on Dropbox for their daily web storage needs. As head of the business side of Dropbox and later CFO, Jaswa had a leading role in this transformati…
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Arthur Brooks on Finding Authentic Happiness and Making Poverty Escapable | Season 1 | Ep 6
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28:15
The United States is the most prosperous and advanced nation in the history of humanity—but it's currently facing a crisis of happiness. What went wrong? Arthur Brooks, Harvard professor, best-selling author, and renowned social scientist, has dedicated himself to tackling America's satisfaction deficit, and in this episode, he reveals his four key…
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Palmer Luckey on Creating Oculus Rift, Anduril, and Game-Changing Defense Tech | Season 1 Ep 5
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Palmer Luckey is as close as it gets to a real-life Iron Man. As a teenager, he worked on virtual reality headsets until he eventually created the Oculus Rift, the most groundbreaking VR headset ever assembled. After single-handedly shaping the field of virtual reality, and selling Oculus to Facebook, he founded Anduril, one of the fastest-growing …
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Bari Weiss on Defending Western Civ and the New School Movement | Season 1 Ep 4
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30:00
This moment in our culture was made for a writer and thinker like Bari Weiss. What can Americans do to beat back the wave of illiberalism currently sweeping through our institutions? Bari Weiss took her stand last summer, resigning from the New York Times to launch her own Substack newsletter. Her courage has since inspired others to defend free sp…
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Kimbal Musk on Building Great Companies and Community | Season 1 Ep 3
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31:09
When Kimbal and Elon Musk immigrated to the U.S. from South Africa to start their first company, they couldn't afford both an apartment and an office—so, unbeknownst to their employees, they slept in the office. The brothers have come a long way from their humble origins. Today, Kimbal is a highly successful entrepreneur and investor who serves on …
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Ashton Kutcher: China, TikTok, and Influencing American Minds | Season 1 Ep 2
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More than 70 percent of child sex trafficking happens online. When Hollywood superstar Ashton Kutcher first heard this statistic, he knew he had to do something to stop it. His efforts took him to Silicon Valley—where, hoping to enlist leading tech entrepreneurs in the fight against online trafficking, he first met Joe. Through their work together,…
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Dr. Rick Klausner on the Biotech Revolution | Season 1 Ep 1
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Curing cancer, eliminating diseases, reprogramming cells to help 80-year-olds feel like they're 30 -- could it all be possible in our generation? America is in the midst of a biotech revolution that is transforming modern medicine and will save countless lives. At the forefront is Dr. Rick Klausner, former director of the U.S. National Cancer Insti…
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