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“Got Knowledge Doc” Podkast with Dr. RR Baliga The "Got Knowledge Doc" Podkast, hosted by Dr. Ragavendra R. Baliga, is a knowledge-driven platform designed for physicians and healthcare providers seeking to stay at the forefront of medical science and innovation. With a distinguished career in cardiovascular medicine and academic leadership, Dr. Baliga engages with leading experts to explore cutting-edge research, emerging technologies, and transformative insights in medicine and beyond. Eac ...
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Summary: Cold-Related Deaths in the US (1999–2022) 1. Overview and Trends • Cold-related deaths more than doubled over the study period. • 40,079 deaths recorded; age-adjusted mortality rate (AAMR) rose from 0.44 (1999) to 0.92 (2022) per 100,000 population (109% increase). • A significant upward trend began in 2017, with an annual percentage chang…
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The AZALEA–TIMI 71 trial compared abelacimab, a monoclonal antibody targeting factor XI, with rivaroxaban in atrial fibrillation patients at moderate-to-high stroke risk. 🚨 New study: Abelacimab vs. Rivaroxaban in AFib 📊 ✅ 62-69% lower bleeding risk than rivaroxaban ✅ 5x lower GI bleeding ⚠️ Slightly higher ischemic stroke rates A promising safer a…
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The Tri.Fr Randomized Clinical Trial evaluated the efficacy of Transcatheter Edge-to-Edge Repair (T-TEER) + Optimized Medical Therapy (OMT) versus OMT alone in 300 patients with severe, symptomatic tricuspid regurgitation (TR) across 24 centers in France and Belgium. At 1-year follow-up, 74.1% of patients in the T-TEER group improved, compared to 4…
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Three studies examined the health impacts of aircraft noise exposure. The Heathrow Study (2023) found that nighttime aircraft noise increased cardiovascular events, particularly between 22:00–23:00 and 04:30–06:00, likely due to sleep disturbance and stress-related mechanisms. 🚨 New studies link aircraft noise to serious health risks! 🛩️🔊 📌 Nightti…
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🚨 Air traffic controllers face severe fatigue due to the 2-2-1 shift system, causing sleep loss, cognitive impairment & safety risks. 🛑 FAA & NATCA now plan to replace it with a safer schedule to enhance aviation safety. ✈️ #Fatigue #AviationSafety #ATC The 2-2-1 shift system in air traffic control (ATC) compresses five shifts into four days, leadi…
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The POPular PAUSE TAVI trial investigated whether continuing or interrupting oral anticoagulation during transcatheter aortic valve implantation (TAVI) affected clinical outcomes. The randomized, open-label, noninferiority study included 858 patients and assessed a composite primary outcome of cardiovascular death, stroke, myocardial infarction, ma…
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The six orthodox Indian schools of philosophy—Nyaya, Vaisheshika, Samkhya, Yoga, Mimamsa, and Vedanta—offer valuable insights into the mind-body connection, ethics, logic, and holistic well-being. Understanding these systems can benefit healthcare providers and patients in promoting mental, emotional, and physical health.…
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The TCW Trial compared TAVI + FFR-guided PCI versus SAVR + CABG in patients with severe aortic stenosis and complex coronary artery disease. This multicenter, randomized controlled trial included 172 patients aged ≥70 years. At 1 year, the primary composite endpoint (death, MI, stroke, revascularization, valve reintervention, or major bleeding) was…
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🚑 New studies on #OHCA: No significant survival benefit of intraosseous (IO) over IV access. IV remains the preferred route, with IO as backup. #EmergencyMedicine #CPR #CardiacArrest These 2 randomized clinical trials compared intraosseous (IO) vs. IV vascular access in out-of-hospital cardiac arrest (OHCA). The first study (Denmark) found no signi…
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🚨 New study: Evolocumab shows strong CV benefits in older adults (≥75 yrs) with ASCVD! 📉 Lower LDL-C, reduced events (HR: 0.79, NNT: 19), & no major safety concerns. Time to rethink lipid guidelines for seniors? 🔬💙 #Cardiology #LipidLowering #EvolocumabVon MasterMedFacts LLC
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Lipoprotein(a) [Lp(a)] is a genetically determined risk factor for atherosclerotic cardiovascular disease (ASCVD) and aortic stenosis. Traditional lipid-lowering therapies have minimal impact on Lp(a), necessitating novel treatments. Zerlasiran, a small-interfering RNA (siRNA), significantly reduces Lp(a) (~85%) by inhibiting hepatic apolipoprotein…
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1. NEJM Article (2024): A 30-year study of 27,939 U.S. women found that high-sensitivity CRP, LDL cholesterol, and lipoprotein(a) independently predicted cardiovascular risk. Higher levels of these biomarkers increased the risk of major cardiovascular events, emphasizing the need for early screening and prevention in women. 2. BrJSportsMed Article …
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1. “Bioaccumulation of Microplastics in Decedent Human Brains” (Nature Medicine, 2024) This study confirms the presence of microplastics and nanoplastics (MNPs) in human brain tissue, particularly the frontal cortex. Researchers used pyrolysis gas chromatography-mass spectrometry (Py-GC/MS) and electron microscopy to analyze postmortem samples, fin…
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Kapila: Founder of Samkhya Philosophy Kapila (7th–6th century BCE) is regarded as the founder of the Samkhya school, one of the six orthodox systems of Hindu philosophy. Known for his rational and dualistic approach, he emphasized the distinction between Purusha (consciousness) and Prakriti (matter). His teachings are captured in the Samkhya Sutras…
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Coronary CT angiography-guided management of patients with stable chest pain: 10-year outcomes from the SCOT- HEART randomised controlled trial in Scotland Michelle C Williams, Ryan Wereski, Christopher Tuck, Philip D Adamson, Anoop S V Shah, Edwin J R van Beek, Giles Roditi, Colin Berry,Nicholas Boon, Marcus Flather, Steff Lewis, John Norrie, Adam…
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Anaximander of Miletus (c. 610 – c. 546 BCE), a pre-Socratic philosopher and student of Thales, was a pioneer of cosmology, astronomy, and natural philosophy. He introduced the concept of the apeiron (infinite) as the origin of all things, developed early theories on evolution, and created one of the first world maps. His revolutionary ideas laid t…
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“The Protein Puzzle: Debunking Myths About Protein Deficiency in India” This episode explores and debunks the myth of protein deficiency in India, highlighting that most Indians meet their protein needs through balanced diets. It explains the Protein-to-Energy Ratio (PER) and how traditional food pairings like cereals and legumes enhance protein qu…
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Gargi Vachaknavi, an esteemed philosopher and Vedic scholar of ancient India, is celebrated as one of the earliest female intellectuals in recorded history. Known for her profound knowledge of Brahma Vidya, she engaged in rigorous philosophical debates, including a renowned discourse with sage Yajnavalkya on the nature of existence and the ultimate…
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“Discover the legacy of Thales of Miletus, the first Greek philosopher and one of the Seven Sages. Known for proposing ‘all is water,’ pioneering geometry, and predicting a solar eclipse, he laid the foundation for science and rational inquiry. #Philosophy #Thales”Von MasterMedFacts LLC
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COVID-19 in Patients with Heart Disease and Cancer Dr RR Baliga's 'Got Knowledge Doc' Podcasts for Physicians Coronaviruses and the Cardiovascular System Coronavirus Fulminant Myocarditis Case Review COVID-19 in Patients with Cardiovascular Disease and Cancer Sarju Ganatra, Sarah P. Hammond, Anju Nohria JACC: CardioOncology:Accessed online March 20…
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Nature NEWS AND VIEWS 14 May 2024 The phenomenon of genomic imprinting was discovered 40 years ago Some genes carry an ‘imprint’ on either the maternal or the paternal copy, which determines whether or not that copy is expressed. This 1984 discovery changed how scientists think about gene regulation and inheritance. By Anne C. Ferguson-Smith & Mari…
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Dr RR Baliga's 'GOT KNOWLEDGE DOC' Podcasts for Physicians: Cardio-Oncology Rehabilitation in Cancer Patients and Survivors derived from Cardio-Oncology Rehabilitation in Cancer Patients and Survivors: AHA Scientific Statement Circulation. 2019;139:e997–e1012 Not Medical Advice or OpinionVon MasterMedFacts.com
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This episode explores the therapeutic potential of singing for cardiovascular health, highlighting its benefits on respiratory function, emotional well-being, and heart rate variability. It discusses the physiological responses to singing, comparable to moderate exercise, and emphasizes the need for further research to validate these findings. Join…
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Trastuzumab Deruxtecan in Previously Treated HER2-Low Advanced Breast Cancer | NEJM https://www.nejm.org/doi/full/10.1056/NEJMoa2203690#.YsoGdaAS_fY.twitter DESTINY-Changing Results for Advanced Breast Cancer | NEJM https://www.nejm.org/doi/full/10.1056/NEJMe2206661#.YsoGjty1ahE.twitter Early Detection and Monitoring of Vulnerable Myocardium in Pat…
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Fasting for Chemotherapy Induced Heart Failure? Dr RR Baliga's 'Got Knowledge Doc' PodKasts for Physicians de Groot S, Lugtenberg RT, Cohen D, et al. Fasting mimicking diet as an adjunct to neoadjuvant chemotherapy for breast cancer in the multicentre randomized phase 2 DIRECT trial. Nat Commun. 2020;11(1):3083. Published 2020 Jun 23. doi:10.1038/s…
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from the chapter 'Statistics in Medicine' in Baliga's Textbook of Internal Medicine www.MasterMedFacts.com authored by Donna Windish, MD, MPH Associate Professor of Medicine (General Medicine); Director, ACES Faculty Development Program, Internal Medicine; Director, Resident Research, Yale Primary Care Residency Program, Internal Medicine; Program …
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Neutrophil Extracellular Traps (NETs) as Biomarkers and Therapeutic Targets? Dr RR Baliga's 'Got Knowledge Doc' PodKasts for Physicians References Yang L, Liu Q, Zhang X, et al. DNA of neutrophil extracellular traps promotes cancer metastasis via CCDC25 [published online ahead of print, 2020 Jun 11]. Nature. 2020 Thålin C, et al. Neutrophil Extrace…
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